IL-10对非酒精性脂肪性肝病发病的保护机制及其治疗前景

Protective mechanism of interleukin-10 against nonalcoholic fatty liver disease and its prospect in treatment

随着肥胖和代谢综合征的流行,非酒精性脂肪性肝病(NAFLD)已成为我国第一大慢性肝病。然而NAFLD的发病机制尚未完全阐明,近年来研究发现IL-10不仅在自身免疫性疾病、炎症性疾病、恶性肿瘤的发病中起重要作用,而且在NAFLD的发病中起到关键的调节作用。本文就IL-10对NAFLD发病的保护机制及其治疗前景进行综述,以便进一步发掘IL-10在NAFLD诊断以及治疗中的临床价值。

With the prevalence of obesity and metabolic syndrome,nonalcoholic fatty liver disease(NAFLD)has become the largest chronic liver disease in China.However,the pathogenesis of NAFLD remains unclear,and recent studies have found that interleukin-10(IL-10)not only plays an important role in the pathogenesis of autoimmune diseases,inflammatory diseases,and malignant tumors,but also plays a key regulatory role in the pathogenesis of NAFLD.This article reviews the protective mechanism of IL-10 against NAFLD and its prospect in treatment,so as to further explore the clinical value of IL-10 in the diagnosis and treatment of NAFLD.