胰腺癌与糖尿病的关系

Association between pancreatic cancer and diabetes

胰腺癌是一类高度恶性的消化系统肿瘤,总体5年生存率不足10%。近年来,大量研究表明胰腺癌与糖尿病呈双向关系,糖尿病既是胰腺癌的高危因素之一,也是胰腺癌引起的一种副肿瘤现象。2型糖尿病患者的高血糖和高胰岛素血症是发生胰腺癌的危险因素;相反胰腺癌细胞通过自分泌或旁分泌引起胰岛β细胞功能受损,导致胰源性糖尿病的发生。本文对流行病学、发病机制及胰腺癌与糖尿病的双向关系作一综述,为临床提供参考。

Pancreatic cancer is a type of highly malignant digestive system tumor,with a 5-year overall survival rate of < 10%. In recent years,a large number of studies have shown that there is a two-way relationship between pancreatic cancer and diabetes;diabetes is not only one of the high-risk factors for pancreatic cancer,but also a paraneoplastic phenomenon caused by pancreatic cancer. Hyperglycemia and hyperinsulinemia in patients with type 2 diabetes are risk factors for pancreatic cancer,and on the contrary,pancreatic cancer cells cause the dysfunction of pancreatic β cells through autocrine or paracrine pathways and thus lead to the onset of pancreatic diabetes. This article reviews the epidemiology and pathogenesis of pancreatic cancer and the two-way relationship between pancreatic cancer and diabetes,so as to provide a reference for clinical practice.