胰腺癌动物模型的比较与选择

Comparison and selection of animal models of pancreatic cancer

胰腺癌(PC)发病隐匿、进展快、预后差,目前,其临床治疗尚无标准方案,而新的靶向治疗获益率并不明显,导致PC的死亡率极高。因此,认识PC的发生、发展机制成为目前亟待解决的首要难题,而建立可靠的PC动物模型,是深入探讨PC发生发展、侵袭、转移机制及优化有效治疗靶点的基础。目前,大量的研究已建立了多种PC动物模型,本文现对各种常用的动物模型进行比较,为PC研究过程中动物模型的选择提供一定的参考。

Pancreatic cancer(PC)has the characteristics of insidious onset,rapid progression,and poor prognosis.Up to now,there are no standard clinical regimens for the treatment of PC,and the benefit rate of new targeted therapy remains at a relatively low level,which results in the high mortality rate of PC.Therefore,an understanding of the development and progression mechanisms for PC has become a difficult issue to be solved,and establishment of reliable animal models for PC is the basis for exploring the development,progression,invasion,and metastasis of PC and the optimization of effective therapeutic targets.At present,a large number of studies have established various animal models for PC,and this article compares the commonly used animal models to provide a reference for the selection of animal models in PC research.