盐酸普拉克索辅助治疗帕金森病对MDA、SOD水平及HAMA、HAMD评分的影响研究

Effect of pramexol hydrochloride adjuvant therapy on MDA,SOD levels and HAMA and HAMD scores of Parkinson′s disease

目的探讨盐酸普拉克索辅助治疗帕金森病(PD)的临床效果及对氧化应激指标、心理状态的影响。方法选取2019年2月至2021年1月于该院就诊的82例PD患者为研究对象,按随机数字表法分为观察组和对照组,每组41例。对照组口服左旋多巴治疗,观察组加用盐酸普拉克索治疗,持续用药3个月。比较两组临床疗效、氧化应激指标、心理状态及不良反应发生情况。结果观察组总有效率为95.12%,高于对照组的80.49%,差异有统计学意义(P<0.05);治疗后观察组超氧化物歧化酶水平高于对照组,丙二醛水平、汉密尔顿焦虑量表评分、汉密尔顿抑郁量表评分低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论盐酸普拉克索辅助治疗PD可提高治疗效果,减轻机体氧化应激反应,纠正患者异常心理状态,安全可靠。

Objective To investigate the clinical effect of pramexol hydrochloride in the adjuvant treatment of Parkinson′s disease(PD)and its effect on oxidative stress index and psychological state.Methods A total of 82 PD patients admitted to the hospital from February 2019 to January 2021 were selected as research objects and divided into observation group and control group according to random number table method,with 41 cases in each group.The control group was treated with levodopa orally,and the observation group was treated with pramexol hydrochloride for 3 months.The clinical efficacy,oxidative stress index,psychological state and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 95.12%,which was higher than that of the control group(80.49%),the difference was statistically significant(P<0.05).After treatment,the level of superoxide dismutase in the observation group was higher than that in the control group,and the level of malondialdehyde,Hamilton Anxiety Scale score and Hamilton Depression Scale score were lower than those in the control group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Pramexol hydrochloride adjuvant therapy can improve the therapeutic effect of PD,reduce the oxidative stress reaction,correct the abnormal psychological state of patients,safe and reliable.