不同情况淋巴瘤患者血清LDH、β_(2)-MG、IL-2R及IL-10水平变化及临床意义

Changes in serum LDH,β_(2)-MG,IL-2R and IL-10 levels in patients with different conditions of lymphoma and their clinical significance

目的探讨不同情况淋巴瘤患者血清乳酸脱氢酶(LDH)、β_(2)微球蛋白(β_(2)-MG)、白细胞介素(IL)-2R、IL-10水平变化及临床意义。方法选取2018-2021年于该院确诊的50例淋巴瘤患者作为淋巴瘤组,收集其血清标本及年龄、性别、淋巴瘤组织、组织免疫学类型、临床分期、骨髓浸润、EB病毒(EBV)感染等资料。同期收集20例体检健康者(对照组)血清标本及资料,比较淋巴瘤组与对照组血清LDH、β_(2)-MG、IL-2R、IL-10水平;分析各指标在淋巴瘤组织、组织免疫学类型,临床分期、骨髓浸润、EBV感染及有效治疗后水平变化情况。结果淋巴瘤组血清LDH、β_(2)-MG、IL-2R、IL-10水平高于对照组(P<0.05);EBV+患者血清LDH、β_(2)-MG、IL-2R水平高于EBV-患者(P<0.05);随着病情进展,临床分期Ⅲ~Ⅳ期和有骨髓浸润患者血清LDH、β_(2)-MG、IL-2R水平高于临床分期Ⅰ~Ⅱ期及无骨髓浸润患者(P<0.05);治疗后淋巴瘤患者血清LDH、β_(2)-MG、IL-2R、IL-10水平较治疗前降低。结论监测血清LDH、β_(2)-MG、IL-2R、IL-10水平变化对淋巴瘤患者的辅助诊断、EBV感染、临床分期、疗效及预后评估具有重要的临床价值。

Objective To investigate the changes of serum lactate dehydrogenase(LDH),β_(2)-microglobulin(β_(2)-MG),interleukin(IL)-2R,IL-10 levels and clinical significance in patients with different conditions of lymphoma.Methods A total of 50 patients with lymphoma diagnosed at the hospital from 2018-2021 were selected as the lymphoma group,their serum specimens and data about age,sex,lymphoma tissue,tissue immunological type,clinical stage,bone marrow infiltration and Epstein-barr virus(EBV)infection were collected.Serum specimens and data were collected from 20 physically healthy individuals(control group)during the same period,serum LDH,β_(2)-MG,IL-2R and IL-10 levels were compared between the lymphoma group and the control group.The changes in the level of each index in lymphoma tissue,tissue immunological type,clinical stage,bone marrow infiltration,EBV infection and after effective treatment were analyzed.Results Serum LDH,β_(2)-MG,IL-2R and IL-10 levels in the lymphoma group were higher than those in the control group(P<0.05).Serum LDH,β_(2)-MG and IL-2R levels in EBV+patients were higher than those in EBV-patients(P<0.05).As the disease progressed,serum LDH,β_(2)-MG and IL-2R levels in patients with clinical stageⅢ-Ⅳand bone marrow infiltration were higher than those in patients with clinical stageⅠ-Ⅱand no bone marrow infiltration(P<0.05).Serum LDH,β_(2)-MG,IL-2R and IL-10 levels decreased in lymphoma patients after treatment compared with those before treatment.Conclusion Monitoring changes in serum LDH,β_(2)-MG,IL-2R and IL-10 levels is of great clinical value for the adjuvant diagnosis,EBV infection,clinical staging,efficacy and prognostic assessment of patients with lymphoma.