蛋白质乙酰化修饰在病毒感染过程中的作用

The Role of Protein Acetylation during Viral Infection

蛋白质乙酰化是一种蛋白质翻译后修饰(post-translational modification,PTM),参与调控多种生物学过程。当病毒感染宿主时,病毒可利用乙酰化修饰便于其自身的复制和增殖;同时,宿主也会启动自身的抗病毒天然免疫反应以应对外来物质,达到保护自身以及限制病毒的增殖,甚至清除病原体的目的。该文主要从病毒与宿主两个角度综述蛋白质乙酰化修饰在病毒感染过程的作用。

Protein acetylation is a kind of PTM (post-translational modification) of the protein,which can participate in regulating various biological processes.When the virus infects the host,the virus will employ acetylation machinery to influence its replication and proliferation.At the same time,the host will also initiate its own antiviral innate immune response to deal with foreign matter for protecting itself,limiting the proliferation of the virus,and even eliminating pathogens.In this paper,the roles of protein acetylation modification during viral infection are reviewed from the perspectives of the virus and host.