不同感染途径艾滋病患者的反应抑制

Response inhibition of AIDS patients with different infection routes

目的探讨不同感染途径艾滋病患者反应抑制的基线水平及其对情绪刺激的反应抑制。方法在云南省传染病医院选取静脉注射、异性性行为、同性性行为感染的艾滋病患者,在云南师范大学选取在校学生作为对照组。采用标准与情绪性停止信号任务范式,要求被试根据指导语的要求做出按键反应或停止按键反应,记录被试的停止信号反应时等数据。结果在标准任务中,四组被试的停止信号反应时差异无统计学意义[F(3,111)=1.64,P=0.184]。在情绪性任务中,组别主效应有统计学意义[F(3,111)=6.27,P<0.05,η^(2)=0.15],同性性行为组的停止信号反应长于其他三组(Ps<0.05)。在两个实验中,静脉注射组的执行反应时显著更短[F(3,111)_(标准)=8.22,P<0.001,η^(2)=0.18;F(3,111)_(情绪)=15.07,P<0.001,η^(2)=0.29]而抑制失败率显著更高[F(3,111)_(标准)=12.27,P<0.001,η^(2)=0.25;F(3,111)_(情绪)=15.37,P<0.001,η^(2)=0.29],同性性行为组的执行反应时均显著更长。结论艾滋病患者的反应抑制不存在缺陷,没有表现出高攻击性,其反应抑制会受感染途径与情绪刺激的影响。

Objective To explore the baseline level of response inhibition and response inhibition to emotional stimulation of AIDS patients through different infection routes.Methods Patients infected with HIV through intravenous injection,heterosexual and homosexual behavior were selected in Yunnan Infectious Disease Hospital.Students from Yunnan Normal University were selected as the control group.The standard and emotional stop signal task paradigms were used to ask the subjects to make keystroke reactions or stop reactions according to the requirements.In addition,their stop-signal response time was recorded.Results In stop-signal task paradigm,there was no significant difference in the stop-signal response time among the four groups[F(3,111)=1.64,P=0.184].However,in the emotional task,the group's main effect was statistically significant[F(3,111)=6.27,P<0.05,η^(2)=0.15],the stop-signal response time of the MSM group was significantly longer than the other three groups(Ps<0.05).In the two experiments,the IDU group's Go task reaction time was significantly shorter[F(3,111)_(standard)=8.22,P<0.001,η^(2)=0.18;F(3,111)_(emotional)=15.07,P<0.001,η^(2)=0.29]and the inhibition failure rate was significantly higher[F(3,111)_(standard)=12.27,P<0.001,η^(2)=0.25;F(3,111)_(emotional)=15.37,P<0.001,η^(2)=0.29],while MSM group's Go task reaction time was significantly longer.Conclusions There is no defect in the response inhibition of AIDS patients,and they do not show high aggressiveness.However,the infection route and emotional stimulation will affect the response inhibition of AIDS patients.