养阴化瘀方联合常规西药治疗快速性心律失常临床研究

Clinical Study on Yangyin Huayu Prescription Combined with Routine Western Medicine for Tachyarrhythmia

目的:观察养阴化瘀方联合常规西药治疗快速性心律失常的临床疗效。方法:选取103例快速性心律失常患者作为研究对象,按随机数字表法分为观察组51例和对照组52例。对照组给予常规西药治疗,观察组在对照组基础上加用养阴化瘀方治疗。比较2组临床疗效、治疗前后心电图指标、中医证候评分、血清学指标的变化。结果:观察组总有效率为94.12%,高于对照组80.77%(P<0.05)。2组治疗后心率、ST段下移幅度、QRc间期较治疗前下降,PR间期较治疗前增高(P<0.05);观察组治疗后心率、ST段下移幅度、QRc间期低于对照组,PR间期高于对照组(P<0.05)。治疗后,2组各项中医证候评分较治疗前下降(P<0.05),观察组各项中医证候评分低于对照组(P<0.05)。2组治疗后血栓素-B2(TXB2)、内皮素-1(ET-1)水平较治疗前下降,一氧化氮(NO)水平较治疗前增高(P<0.05);观察组治疗后TXB2、ET-1水平低于对照组,NO水平高于对照组(P<0.05)。结论:养阴化瘀方联合常规西药治疗快速性心律失常效果显著,可减轻临床症状,改善心电图指标和内皮细胞功能。

Objective:To observe the clinical effect of Yangyin Huayu Prescription combined with routine western medicine for tachyarrhythmia.Methods:A total of 103 cases of patients with tachyarrhythmia were selected as study objects and were divided into the observation group and the control group according to the random number table method,with 51 and 52 cases in each group respectively.The control group was treated with routine western medicine,and the observation group was additionally treated with Yangyin Huayu Prescription based on the treatment of the control group.The changes in electrocardiogram indexes,Chinese medicine syndrome scores and serological indexes before and after treatment as well as the clinical effects in the two groups were compared.Results:The total effective rate was 94.12% in the observation group,higher than that of 80.77% in the control group(P<0.05).After treatment,heart rates,ST-segment descending amplitudes and QRc intervals in the two groups were decreased and the PR intervals were increased when compared with those before treatment(P<0.05);the heart rate,ST-segment descending amplitude and QRc interval in the observation group were lower and the PR interval was higher than those in the control group(P<0.05).After treatment,TCM syndrome scores in the two groups were decreased when compared with those before treatment(P<0.05),and the Chinese medicine syndrome score in the observation group was lower than that in the control group(P<0.05).After treatment,the levels of thromboxane-B2(TXB2)and endothelin-1(ET-1)in the two groups were decreased when compared with those before treatment,and the levels of nitric oxide(NO)were increased(P<0.05);the levels of TXB2 and ET-1 in the observation group were lower and the level of NO was higher than those in the control group(P<0.05).Conclusion:The therapy of Yangyin Huayu Prescription combined with routine western medicine for tachyarrhythmia has a significant effect,which can relieve clinical symptoms,improve electrocardiogram indexes and endothelial function.