麝香通心滴丸联合常规西药治疗急性心肌梗死PCI术后患者的效果

Effects of Shexiang Tongxin dropping pills combined with conventional western medicine on patients with acute myocardial infarction after PCI

目的:观察麝香通心滴丸联合常规西药治疗急性心肌梗死(AMI)经皮冠状动脉介入治疗(PCI)术后患者的效果。方法:选取2019年10月至2020年12月该院收治的94例AMI PCI术后患者进行前瞻性研究,按照随机数字表法分为观察组与对照组各47例。对照组给予常规西药治疗,观察组在对照组基础上给予麝香通心滴丸治疗,比较两组治疗前后中医证候积分、血液流变学指标[全血低切黏度(NBL)、血浆黏度(PV)和全血高切黏度(NBH)]水平和血管内皮功能指标[血清内皮素-1(ET-1)、一氧化氮(NO)、可溶性血管细胞粘附分子-1(sVCAM-1)]水平。结果:治疗后,两组心胸刺痛、气短乏力、胸闷和心悸多汗等中医证候积分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组NBL、PV、NBH水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,观察组ET-1、sVCAM-1水平低于对照组,NO水平高于对照组,差异有统计学意义(P<0.05)。结论:麝香通心滴丸联合常规西药治疗AMI PCI术后患者可降低中医证候积分和血液流变学指标水平,改善血管内皮功能指标水平,效果优于单纯常规西药治疗。

Objective: To observe effects of Shexiang Tongxin dropping pills combined with conventional western medicine on patients with acute myocardial infarction(AMI) after percutaneous coronary intervention(PCI). Methods: A prospective study was conducted on 94patients with AMI after PCI admitted to the hospital from October 2019 to December 2020. They were divided into observation group and control group according to the random number table method, 47 cases in each. The control group was treated with conventional western medicine, while the observation group was treated with Shexiang Tongxin dropping pills on the basis of that of the control group. The TCM syndrome score, the hemorheology index levels [whole blood low shear viscosity(NBL), plasma viscosity(PV) and whole blood high shear viscosity(NBH)], and the vascular endothelial function index levels [serum endothelin-1(ET-1), nitric oxide(NO), soluble vascular cell adhesion molecule-1(sVCAM-1)] were compared between the two groups before and after the treatment. Results: After the treatment, the scores of TCM syndromes such as cardiothoracic stabbing pain, shortness of breath, fatigue, chest tightness and palpitation and sweating in the two groups were lower than those before the treatment,those in the observation group were lower than the control group, and the differences were statistically significant(P<0.05). After the treatment, the levels of NBL, PV and NBH in the two groups were lower than those before the treatment, those in the observation group were lower than those in the control group, and the differences were statistically significant(P<0.05). After the treatment, the levels of ET-1 and sVCAM-1 in the observation group were lower than those in the control group, the level of NO was higher than that in the control group, and the differences were statistically significant(P<0.05). Conclusions: Shexiang Tongxin dropping pills combined with conventional western medicine in the treatment of the patients with AMI after PCI can reduce the TCM syndrome score and the levels of hemorheology indexes, and improve the levels of vascular endothelial function indexes. Moreover, it is superior to single conventional western medicine treatment.