血清ALB、CHE、ALT、γ-GT水平检测在肝硬化诊断中的应用价值

Application value of serum ALB, CHE, γ-GT and ALT in diagnosis of liver cirrhosis

目的:探讨血清白蛋白(ALB)、胆碱酯酶(CHE)、丙氨酸氨基转移酶(ALT)和γ-谷氨酰转肽酶(γ-GT)水平检测在肝硬化诊断中的应用价值。方法:选取2019年1月至2021年6月本院收治的75例肝硬化患者为肝硬化组。选取同期于本院体检的75名健康人作为对照组,两组均行血清ALB、ALT、CHE、γ-GT水平检测。比较两组血清ALB、ALT、CHE、γ-GT水平,比较肝硬化组不同肝功能分级患者血清ALB、ALT、CHE、γ-GT水平,采用Spearman相关性分析,探讨血清ALB、ALT、CHE、γ-GT水平与肝硬化患者肝功能的相关性。结果:肝硬化组血清ALB、CHE水平低于对照组,ALT、γ-GT水平高于对照组,差异均有统计学意义(P<0.05)。75例肝硬化患者中,Child-Pugh分级为A级24例,B级32例,C级19例。C级肝硬化患者ALB、CHE水平均低于B级和A级患者,且B级低于A级;C级肝硬化患者ALT、γ-GT水平均高于B级和A级患者,且B级高于A级,差异均有统计学意义(P<0.05)。Spearman相关性分析结果显示,血清ALB、CHE水平与肝硬化患者肝功能Child-Pugh分级呈负相关(r<0,P<0.05);血清ALT、γ-GT水平与肝硬化患者肝功能Child-Pugh分级呈正相关(r>0,P<0.05)。结论:血清ALB、CHE、γ-GT、ALT水平用于肝硬化诊断具有临床价值,可反映肝硬化患者肝功能。

Objective: To investigate application value of serum albumin(ALB), cholinesterase(CHE), alanine aminotransferase(ALT) and γ-glutamyl transpeptidase(γ-GT) in diagnosis of liver cirrhosis. Methods: 75 patients with liver cirrhosis admitted to this hospital from January 2019 to June 2021 were selected as cirrhosis group, and 75 healthy people who underwent physical examination during the same period were selected as control group. The serum ALB, ALT, CHE and γ-GT levels were detected in both groups. The levels of serum ALB, ALT, CHE and γ-GT were compared between the two groups. The levels of serum ALB, ALT, CHE and γ-GT in the patients with different liver function classifications in the cirrhosis group were compared. Spearman correlation analysis was used to investigate the correlations among the serum ALB, ALT, CHE, γ-GT levels and the liver function in the patients with liver cirrhosis. Results: The levels of serum ALB and CHE in the liver cirrhosis group were lower than those in the control group, the levels of ALT and γ-GT were higher than those in control group, and the differences were statistically significant(P<0.05). Among the 75 patients with liver cirrhosis, 24 cases had Child-Pugh classification A, 32 cases had the classification B, and 9 cases had the classification C. The levels of ALB and CHE in the patients with Child-Pugh classification C were lower than those in the patients with classification B and classification A, and those in the patients with classification B were lower than those in the patients with classification A;the levels of ALT and γ-GT in the patients with Child-Pugh classification C cirrhosis were higher than those in the patients with classification B and classification A, and those in the patients with classification B higher lower than those in the patients with classification A;and the differences were statistically significant(P<0.05). Spearman correlation analysis showed that the serum ALB and CHE levels were negatively correlated with the Child-Pugh classification of liver function in the patients with liver cirrhosis(r<0, P<0.05), while the serum ALT and γ-GT levels were positively correlated with the Child-Pugh classification(r>0, P<0.05). Conclusions: The serum ALB, CHE, γ-GT and ALT levels have clinical value in the diagnosis of liver cirrhosis, which can reflect the liver function of the patients with liver cirrhosis.