比较艾司西酞普兰和帕罗西汀对抑郁症患者的效果和不良反应

The comparison of effect and adverse reactions between escitalopram and paroxetine in treatment of depression patients

目的比较抑郁症患者治疗中应用艾司西酞普兰和帕罗西汀的效果和不良反应。方法遴选时段2019年6月~2020年6月内60例抑郁症患者,根据随机数字表法分2组,接受盐酸帕罗西汀30例(对照组),接受草酸艾司西酞普兰治疗30例(观察组)。对比指标:临床总疗效、负面情绪评分用汉密尔顿焦虑量表(Hamilton Anxiety Scale,HAMA)和汉密尔顿抑郁量表(Hamilton Depression Scale,HAMD)、生活质量评分使用健康状况调查简表(the MOS item short from health survey,SF-36)、不良反应率。结果观察组患者用药总疗效较对照组显著高(P<0.05);且两组不良反应率比较无统计学差异(P>0.05);两组治疗前HAMD评分、HAMA评分比较无统计学差异(P>0.05),两组治疗后的HAMD评分、HAMA评分较同组治疗前均显著下降,且观察组明显低于对照组(P<0.05);两组治疗前生活质量评分比较,无统计学差异(P>0.05),两组治疗后生活质量评分均显著升高,且观察组角色功能、社会功能、躯体功能、认知能力评分均较对照组明显高(P<0.05)。结论草酸艾司西酞普兰治疗抑郁症患者,整体疗效更好,控制病情进展,改善患者抑郁症状,同时促进生活质量大幅度提高,且用药安全性有保障。

Objective To compare between the effect and adverse reactions between escitalopram and paroxetine in treatment of depression patients.Methods 60 patients with depression from June 2019 to June 2020 were selected and divided into two groups according to the random number table.30 patients received paroxetine hydrochloride(control group)and 30 patients received escitalopram oxalate(observation group).Comparative indicators included total clinical efficacy,negative emotion score[Hamilton Anxiety Scale(HAMA)],Hamilton Depression Scale Hamilton Depression Scale(HAMD),quality of life score[the MOS item short from health survey,SF-36],adverse reaction rate.Results The total curative effect of the observation group was significantly higher than that of the control group(P<0.05).There was no significant difference in the rate of adverse reactions between the two groups(P>0.05).At the same time,there was no significant difference in HAMD score and HAMA score between the two groups before treatment(P>0.05).After treatment,HAMD score and HAMA score of the two groups were significantly lower than those of the same group before treatment,and the observation group was significantly lower than that of the control group(P<0.05).There was no significant difference in the scores of quality of life between the two groups before treatment(P>0.05).The scores of quality of life in the two groups increased significantly after treatment,and the scores of role function,social function,physical function and cognitive ability in the observation group were significantly higher than those in the control group(P<0.05).Conclusion The escitalopram oxalate had better overall efficacy in the treatment of patients with depression,which can control the progress of the disease,improve the depressive symptoms of patients,greatly improve the quality of life,and ensure the safety of medication.