变异链球菌氧化应激调控机制的研究进展

Research progress on oxidative stress regulatory mechanisms in Streptococcus mutans

龋病发生发展与牙菌斑生物膜微生态平衡密切相关。氧化应激是调控口腔微生物群落组成及结构的重要因素。变异链球菌与龋病的发生发展密切相关,变异链球菌氧化应激耐受能力会影响其在牙菌斑生物膜中的竞争力。变异链球菌氧化应激调控机制包括合成还原酶、通过金属调节蛋白调控铁、锰等金属离子摄入、转录调节因子Spx、从胞外摄取谷胱甘肽及相关的信号传导系统等。目前的研究焦点为变异链球菌如何通过氧化应激反应适应复杂的外环境及对口腔微生态的影响。通过针对关键信号通路设计靶向小分子化合物等途径,抑制变异链球菌氧化应激能力,削弱其毒力,对于口腔微生态调节和龋病防治具有重要意义。

The oral microecological balance is closely associated with the development of dental caries.Oxidative stress is one of the important factors regulating the composition and structure of the oral microbial community.Strepto⁃coccus mutans is closely related to the occurrence and development of dental caries.The ability of S.mutans to with⁃stand oxidative stress affects its survival competitiveness in biofilms.The oxidative stress regulatory mechanisms of S.mutans include the synthesis of reductase,the regulation of iron and manganese uptake by metalloregulatory proteins,transcription regulator Spx,extracellular uptake of glutathione and other related signal transduction systems.The cur⁃rent research focuses on how S.mutans adapts to a complex external environment through an oxidative stress response and its influence on oral microecology.We can design targeted small molecular compounds for key signaling pathways to inhibit oxidative stress and weaken the virulence of S.mutans,which is important for oral microecological modulation and dental caries prevention and treatment.