橙皮苷对心血管疾病危险因素影响研究的进展

Research progress of influence of hesperidin on risk factors of cardiovascular diseases

橙皮苷已成为一种能够调节多种心血管疾病危险因素的新型潜在治疗剂。橙皮苷在糖尿病模型中显示出降低葡萄糖和抗炎的特性,在心血管疾病和肥胖模型中显示出预防血脂异常,动脉粥样硬化和肥胖症的作用,在高血压模型中显示出抗高血压和抗氧化作用。然而橙皮素在人体研究缺乏结论性结果可能部分是由于橙皮苷在肠道菌群、生物利用度方面的个体差异,本文就橙皮苷对心血管疾病危险因素作用及其在人体利用方面的近年研究进展进行综述。

Hesperidin has become a new potential therapeutic agent that can regulate many risk factors of cardiovascular diseases(CVDs).Hesperidin showed glucose-lowering and anti-inflammatory properties in diabetes mellitus model;and preventing dyslipidemia,atherosclerosis,and obesity effects in CVDs and obesity models;and antihypertensive and antioxidant effects in hypertension model.However,the lack of conclusive results in human studies on hesperidin may be partly due to individual differences in intestinal microbiota and bioavailability of hesperidin.The present article reviews the research progress of hesperidin on risk factors of CVDs and human utilization in recent years.