再生过程中心肌细胞去分化和增殖的研究进展

Recent Advances on Cardiomyocyte Dedifferentiation and Proliferation during Heart Regeneration

心肌梗死严重威胁人类生命健康。损伤的成体哺乳动物心脏无法进行再生,最终导致心力衰竭。多种临床治疗手段可以缓解心肌梗死症状,但无法修复死亡的心肌细胞。斑马鱼等低等脊椎动物以及一些新生哺乳动物心脏受到损伤后可以再生。研究心脏再生的细胞和分子机制可为成体心脏损伤修复提供理论基础。越来越多的研究表明,心脏损伤后心肌细胞的修复依赖于心肌细胞的去分化和增殖。该文简单概述心脏再生过程中心肌细胞的来源以及心肌细胞去分化和增殖的分子机制。

Myocardial infarction is a serious threat to human life and health.The damaged adult mammalian heart is unable to regenerate,eventually leading to heart failure.A variety of clinical treatments can relieve the symptoms of myocardial infarction,but they cannot repair the dead heart cells.Lower vertebrates such as zebrafish and some newborn mammals can regenerate damaged hearts.Research on cellular and molecular mechanisms of cardiac regeneration can provide theoretical basis for the repair of adult cardiac injury.More and more studies have shown that cardiomyocyte repair after cardiac injury depends on the dedifferentiation and proliferation of cardiomyocytes.In this paper,the origin of cardiomyocytes during cardiac regeneration and the molecular mechanisms of the dedifferentiation and proliferation of cardiomyocytes are briefly reviewed.