非编码RNAs在心肌细胞增殖与心脏再生中的作用

Non-Coding RNAs in Cardiomyocyte Proliferation and Cardiac Regeneration

心肌梗死以高发病率、高致死率的特点严重影响人类健康,并造成了极大的社会经济负担。促进心肌细胞增殖与再生是修复缺血导致的心脏损伤的关键。越来越多的研究表明,非编码RNAs参与调控心肌细胞的增殖与再生。该文总结了小RNAs(microRNAs,miRNAs)、长链非编码RNAs(long non-coding RNAs,lncRNAs)以及环状RNAs(circular RNAs,circRNAs)参与调控心肌细胞增殖与再生、修复损伤心脏及其相关的分子机制。此外,该文还展望了非编码RNAs促进心肌细胞增殖的潜在治疗作用以及心脏损伤后应用RNA治疗进行再生修复的前景。

Myocardial infarction is associated with high incidence and mortality,which seriously impacts on human health and places a heavy economic burden on countries worldwide.Stimulating cardiomyocyte proliferation and cardiac regeneration is a key to repair the injured heart caused by ischaemia.Emerging evidences have demonstrated that non-coding RNAs play important roles in cardiac proliferation and regeneration.This review focuses on the function and mechanism that miRNAs(microRNAs),lncRNAs(long non-coding RNAs)and circRNAs(circular RNAs)modulate cardiomyocyte proliferation and regeneration to mend a damaged heart.Furthermore,the potential therapeutic roles of these non-coding RNAs in boosting cardiomyocytes proliferation is highlighted.Finally,this review presents the perspective on the development of non-coding RNA therapy in heart diseases by regeneration.