姜黄素治疗银屑病的机制及其局部递送系统研究进展

Research progress on the mechanism and local delivery system of curcumin in the treatment of psoriasis

银屑病(psoriasis)是一种炎症性皮肤疾病,其临床表现以红斑与鳞屑为主,病程较长,并且较难治愈。姜黄素属于一种酚类物质,提取自中药姜黄(Rhizoma Curcumae Longae),有抗炎、抗氧化、抗肿瘤等药理作用,对于银屑病治疗有一定效果。由于姜黄素存在口服给药利用度低、传统外用给药渗透性差等局限性,为了提高姜黄素的利用率并扩大其在银屑病等慢性皮肤病中的应用,姜黄素局部递送系统的研究成为热点。该文主要综述了姜黄素治疗银屑病的作用机制,并总结了近年来对姜黄素局部药物递送系统的研究进展,为进一步研究姜黄素提供参考。

Psoriasis is a chronic inflammatory skin disease,with erythema,scales as the main clinical manifestations,long course of disease,lingering difficult to recover.Curcumin,a phenolic substance extracted from the traditional Chinese medicine Rhizoma Curcumae Longae,which has anti-inflammatory,antioxidant and anti-tumor effects,and has certain therapeutic effects on psoriasis.Due to the limitations of curcumin such as low oral administration availability and poor permeability of traditional topical administration,in order to improve the utilization rate of curcumin and expand its application in chronic skin diseases such as psoriasis,the studies of curcumin local delivery system have become a hot topic.This paper mainly reviewed the mechanism of curcumin in the treatment of psoriasis and summarized the research progress on the local drug delivery system of curcumin,so as to provide reference for further research on curcumin.