摘要
目的 研究50 Hz工频电磁场致职业暴露人群短时记忆力降低与外周血中Aβ_(1-42)(beta-amyloid peptide 1-42)蛋白浓度的关系。方法 选取51名火电厂电气运行人员为暴露组,26名同厂行政办公人员为对照组,两组人员均进行短时记忆力测试,同时测定外周血中Aβ_(1-42)蛋白浓度,比较两组中相关指标的差异及相关性。结果 暴露组8 h时间加权平均电场强度为1.690 kV/m,磁场强度为4.578μT。对照组8 h时间加权平均电场强度为0.008 kV/m,磁场强度为0.026μT。两组人员数字跨度得分暴露组低于对照组(t=3.702,P<0.001);暴露组失眠出现率(15.69%)和记忆力减退出现率(21.57%)均高于对照组(均有P<0.05);三项情感状态指标得分暴露组低于对照组:愤怒-敌意(t=2.239,P=0.028)、疲劳-惰性(t=2.024,P=0.047)、困惑-迷茫(t=2.489,P=0.015);外周血中Aβ_(1-42)蛋白浓度(pg/mL)暴露组高于对照组(t=-2.414,P=0.018)。数字跨度得分与Aβ_(1-42)蛋白浓度的变化并未发现相关关系(r=-0.173,P=0.133)。结论 50 Hz工频电磁场可致职业人群短时记忆力损伤,并引起外周血中Aβ_(1-42)蛋白浓度变化,但两者之间是否存在因果关系尚需进一步研究确定。
Objective To study the relationship between reduced short-term memory and peripheral blood Aβ_(1-42) protein concentration induced by a 50 Hz power frequency electromagnetic field.Methods Fifty-one thermal power plant electrical operators were selected as the exposure group,and twenty-six administrative staffs of the same plant were selected as the control group.Both groups were tested for short-term memory,and the concentration of Aβ_(1-42) protein in peripheral blood was measured simultaneously.The correlation between the two groups was compared.Results The 8 h time-weighted average intensity of the exposed group was 1.690 kV/m,and the magnetic field intensity was 4.578 μT.In the control group,the average electric field strength was 0.008 kV/m,and the magnetic field strength was 0.026 μT for 8 h time-weighted average electric field intensity.The digit span score of the two groups in the exposed group was significantly lower than that in the control group(t=3.702,P<0.001);the incidence of autonomic symptoms of insomnia(15.69%) and memory loss(21.57%) in the exposed group was significantly higher than the control group(all P<0.05);the scores of three emotional state indicators in the exposed group were significantly lower than those in the control group,which incllding anger-hostility(t=2.239,P=0.028),fatigue-inert(t=2.024,P=0.047),and confusion-confusion(t=2.489,P=0.015);Aβ_(1-42) protein concentration in peripheral blood(pg/mL) with significantly higher in exposure group when compared to the control group(t=-2.414,P=0.018).No correlation was found between digital span scores and changes in Aβ_(1-42) protein concentration(r=-0.173,P=0.133).Conclusions 50 Hz power frequency electromagnetic field can cause short-term memory impairment in the occupational population and change the concentration of Aβ_(1-42) protein in peripheral blood.However,the causal relationship between them needs further study.
作者
边洪英
张尧
王艳
董一文
叶萌
BIAN Hong-ying;ZHANG Yao;WANG Yan;DONG Yi-wen;YE Meng(Department of Occupational Epidemiology and Risk Assessment,National Institute of Occupational Health and Poison Control,Chinese Center for Disease Control and Prevention,Beijing 100050,China;Sichuan Electric Power Hospital,Industrial Sanitation Station,Chengdu 61001l,China)
出处
《中华疾病控制杂志》
CAS
CSCD
北大核心
2022年第11期1326-1331,共6页
Chinese Journal of Disease Control & Prevention
基金
中国疾病预防控制中心职业卫生与中毒控制所青年基金项目(2016PJ03)
职业健康风险评估与国家职业卫生标准制定项目(131031109000160004)。
关键词
工频电磁场
学习记忆力
Aβ_(1-42)蛋白
Power frequency electromagnetic field
Short-term memory impairment
Aβ_(1-42)protein