摘要
茶多酚是茶叶的主要活性物质之一,表没食子儿茶素没食子酸酯(EGCG)则是茶多酚发挥生物作用的主要活性成分。二者作为免疫调节剂可用于肿瘤的治疗。本文从提高免疫效应、改善免疫逃逸两个方面综述茶多酚及EGCG的抗肿瘤作用机制。结果发现,茶多酚及EGCG不仅可以通过活化免疫细胞与促进细胞因子分泌来提高抗肿瘤免疫效应,还可通过调节免疫抑制细胞、调控免疫检查点、调节细胞因子、抑制免疫调节酶与Janus激酶/信号转导和转录激活子(JAK/STAT)通路来改善肿瘤免疫逃逸,在肿瘤免疫治疗方面具有较大潜力。
Tea polyphenol(TP)is the main active constituent in tea,and epigallocatechin gallate(EGCG)is the main active constituent of TP that plays a biological role.Both of them can be used as immunomodulators in the treatment of tumor.In this paper,the anti-tumor mechanism of TP and EGCG was summarized from two aspects:enhancing immune effect and improving immune escape.The results showed that TP and EGCG could not only enhance the anti-tumor immune effect by promoting the activity of immune cells and the secretion of cytokines,but also improve tumor immune escape by regulating immunosuppressive cells,immune checkpoints,cytokines,immunomodulatory enzymes and JAK/STAT pathway,which has great potential in tumor immunotherapy.
作者
李光达
王婧
许晶
谢美雯
周义斌
侯丽
LI Guangda;WANG Jing;XU Jing;XIE Meiwen;ZHOU Yibin;HOU Li(Dept.of Oncology and Hematology,Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China)
出处
《中国药房》
CAS
北大核心
2022年第24期3067-3072,共6页
China Pharmacy
基金
国家自然科学基金资助项目(No.82172760)
首都卫生发展科研专项项目(No.首发2020-2-4193)。