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眼部慢性移植物抗宿主病的治疗 被引量:3

Treatment of chronic ocular graft versus host disease
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摘要 慢性移植物抗宿主病(cGVHD)是异基因造血干细胞移植(allo-HSCT)后的常见并发症,发生率为30%~70%[1]。cGVHD类似于自身免疫性疾病,涉及包括皮肤、肺、肝、胃肠道、口腔、生殖器和眼睛等多个部位。眼部GVHD(oGVHD)的发生率为40%~60%,临床表现轻、重程度不一,但如果不及时治疗和控制,高达60%~90%的患者出现视力下降,严重影响患者日常生活与工作[2-3]。
作者 程先静 袁容娣 张曦 Cheng Xianjing;Yuan Rongdi;Zhang Xi(Medical Center of Hematology,Xinqiao Hospital of Army Medical University,State Key Laboratory of Trauma,Burns and Combined Injury,PLA Blood Disease Center,Chongqing Key Discipline of Medicine,Chongqing400037,China;School of Medicine Chongqing University,Chongqing 400030,China;Ophthalmology Department,Xinqiao Hospital of Army Medical University,Chongqing 400037,China)
出处 《中华血液学杂志》 CAS CSCD 北大核心 2022年第10期877-880,共4页 Chinese Journal of Hematology
基金 国家血液系统疾病临床医学研究中心2020年度开放课题(2020ZKZC02) 国家重点研究计划(2017YFA0105502) 重庆市自然科学基金创新群体基金(cstc2021jcyjcxttX0001)。
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  • 1夏凌辉,邹萍,胡俊斌,游泳,方峻,郭涛,刘芳,张纯,崔国惠,谢薇,宋善俊.异基因造血干细胞移植后慢性移植物抗宿主病的临床分析[J].中华器官移植杂志,2007,28(7):428-432. 被引量:8
  • 2Socie G, J Ritz, PJ Martin. Current challenges in chronic graft- versus-host disease. Biol Blood Marrow Transplant. 16: S146- 151.
  • 3Ogawa Y, Okamoto S, Mori T, et al. Autologous serum eye drops for the treatment of severe dry eye in patients with chronic graft- versus-host disease. Bone Marrow Transplant, 2003,31 : 579- 583.
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  • 6Takahide K, Parker PM, Wu M, et al. Use of FLuid-ventilated, gas-permeable scleral lens for management of severe keratoconjunctivitis sieca secondary to chronic graft-versus-host disease. Biol Blood Marrow Transplant, 2007,13: 1016-1021.
  • 7Wang Y, Ogawa Y, Dogru M, et al. Ocular surface and tear functions after topical cyelosporine treatment in dry eye patients with chronic graft-versus-host disease. Bone Marrow Transplant, 2008,41 : 293-302.
  • 8Rocha EM, Pelegrino FS, de Paiva CS, et al. GVHD dry eyes treated with autologous serum tears. Bone Marrow Transplant, 2000,25 : 1101-1103.
  • 9Joseph RW, Couriel DR, Komanduri KV. Chronic graft-versus- host disease after allogeneic stem cell transplantation: challenges in prevention, science, and supportive care. J Support Oncol, 2008,6:361-372.
  • 10陈静,韩苏宁,邓金印,吴军丽,李欣,陈晓娟,朱海萍.小牛血去蛋白提取物眼凝胶对Epi-LASIK术后角膜上皮修复的影响[J].眼科新进展,2010,30(5):469-471. 被引量:15

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