连续性血液净化对成人腹腔内高压患者器官功能、腹腔内压及胃肠道症状的影响

Effect of Continuous Blood Purification on Organ Function,Intra-abdominal Pressure and Gastrointestinal Symptoms in Patients with Intra-abdominal Hypertension

目的探究连续性血液净化(CBP)对腹腔内高压(IAH)患者器官功能、腹腔内压力(IAP)及胃肠道症状的影响。方法回顾性分析2019年1月至2021年12月郑州大学第二附属医院重症医学科收治的86例成人IAH患者,将前期接受传统临床治疗的40例患者纳入对照组,将后期在传统治疗基础上联用CBP治疗的46例患者纳入观察组,对比两组患者器官功能、IAP及胃肠道症状。结果治疗后,观察组序贯器官衰竭评分(SOFA)、急性生理与慢性健康Ⅱ(APACHEⅡ)评分低于对照组(P<0.05);IAP低于对照组(P<0.05),腹腔灌注压(APP)高于对照组(P<0.05);胃肠功能评分低于对照组,胃肠功能恢复时间短于对照组,胃肠道症状出现例数少于对照组(P<0.05)。结论CBP联合传统临床治疗应用于IAH患者中可有效降低IAH,促进器官功能恢复,减轻胃肠道症状。

Objective To explore the effect of continuous blood purification(CBP)on organ function,intra-abdominal pressure(IAP)and gastrointestinal symptoms in patients with intra-abdominal hypertension(IAH).Methods A retrospective analysis was performed on 86 adult IAH patients admitted to the Department of Critical Care Medicine in the Second Affiliated Hospital of Zhengzhou University from January 2019 to December 2021.Forty patients in the control group were given conventional clinical treatment,and 46 patients in the observation group were treated with CBP on this basis.The organ function,IAP and gastrointestinal symptoms of the two groups were compared.Results After treatment,the observation group’s sequential organ failure score(SOFA),acute physiology and chronic health evaluationⅡ(APACHEⅡ)score were lower than those of the control group(P<0.05).The levels of IAP was lower than that of the control group(P<0.05),while the intra-abdominal perfusion pressure(APP)was higher(P<0.05).The sequential gastrointestinal function score in the observation group was lower than that in the control group,recovery time of gastrointestinal function in the observation group was shorter than that in the control group,and the number of gastrointestinal symptoms was less than that of the control group(P<0.05).Conclusion The application of CBP combined with traditional clinical treatment in patients with IAH can effectively reduce IAH,promote the recovery of organ function,and relieve gastrointestinal symptoms.