补血养心消瘤汤联合临床干预路径对乳腺癌术后患者免疫功能的影响

Effect of Buxue Yangxin Xiaoliu Decoction Combined with Clinical Intervention Pathway on Immune Function of Breast Cancer Patients after Operation

目的 探讨补血养心消瘤汤联合临床干预路径在乳腺癌术后患者中的应用效果。方法 选取河南省信阳市人民医院收治的乳腺癌术后患者80例,选取时间:2018年12月—2020年12月,分为对照组(40例)和观察组(40例)(按照随机数字表法)。CAF方案化疗联合临床干预路径应用于对照组,观察组在对照组的基础上联合使用补血养心消瘤汤。2组患者治疗周期均为24周。比较2组治疗后临床疗效、治疗前后免疫功能及肿瘤标志物水平。结果 治疗后观察组临床总有效率高于对照组;与治疗前比较,治疗后对照组外周血CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)、NK水平均降低,观察组上述指标水平均升高,且比对照组高;对照组治疗后外周血CD8^(+)水平升高,经比较,观察组水平降低,且比对照组低;对照组与观察组治疗后血清CEA、CA153、TS-GF水平均降低,经比较,观察组比对照组低(P<0.05)。结论 补血养心消瘤汤联合临床干预路径可降低乳腺癌术后患者血清肿瘤标志物水平,改善免疫功能,治疗效果显著。

Objective To explore the application effect of Buxue Yangxin Xiaoliu decoction combined with clinical intervention pathway in postoperative breast cancer patients.Methods A total of 80 patients with breast cancer after operation were selected from Xinyang People’s Hospital.The time of selection was from December 2018 to December 2020.They were divided into the control group (40 cases) and the observation group (40 cases) according to random number table.CAF chemotherapy combined with clinical intervention pathway was applied to the control group,and the observation group was combined with Buxue Yangxin Xiaoliu decoction on the basis of the control group.The treatment cycle of the two groups was 24 weeks.The clinical efficacy,immune function and tumor marker levels before and after treatment were compared between the two groups.Results After treatment,the total clinical effective rate in the observation group was higher than the control group.Compared with before treatment,the levels of peripheral blood CD3,CD4,CD4/CD8and NK in the control group decreased after treatment,and the levels of the above indexes in the observation group increased,which was higher than that in the control group;After treatment,the level of peripheral blood CD8in the control group increased.After comparison,the level in the observation group decreased and was lower than that in the control group.The levels of serum CEA,CA153 and TS-GF in the control group and the observation group decreased after treatment.After comparison,the levels of serum CEA,CA153 and TS-GF in the observation group were lower than those in the control group (P<0.05).Conclusion The combination of Buxue Yangxin Xiaoliu decoction and clinical intervention can reduce serum tumor markers and improve immune function in patients with breast cancer after operation.