白脂素在代谢性疾病及心血管疾病中的研究进展

Research progress of asprosin in metabolic diseases and cardiovascular diseases

白脂素(Asprosin)是一种新发现的禁食诱导的生糖脂肪因子,参与调控食欲、糖脂肪代谢以及氧化应激等过程。最近研究发现,白脂素与2型糖尿病、肥胖、非酒精性脂肪性肝病、多囊卵巢综合征等代谢性疾病以及冠心病、扩张型心肌病等心血管疾病的发生相关,并在心脏保护中发挥积极作用。现就其相关研究进行概述。

Asprosin is a newly discovered fasting-induced glucogenic adipokine,which is involved in regulating appetite,glucose and fat metabolism and oxidative stress.Recently,it has been found that asprosin is related to metabolic diseases such as type 2 diabetes,obesity,nonalcoholic fatty liver,polycystic ovary syndrome,and cardiovascular diseases such as coronary heart disease and dilated cardiomyopathy,and plays an active role in heart protection.In this paper,the related research progress is summarized.