慢性萎缩性胃炎证候要素分布规律的相关性分析

Correlation analysis of syndrome elements distribution in chronic atrophic gastritis

[目的]探讨慢性萎缩性胃炎证候要素的分布规律。[方法]临床采集慢性萎缩性胃炎患者中医四诊信息、胃镜及病理检查报告并建立慢性萎缩性胃炎病历数据库;采用因子分析、对应分析、类神经网络建模的多元统计方法分析慢性萎缩性胃炎证候要素分布情况、证候要素间关联性以及重要病理改变与证候要素间相关性。[结果]慢性萎缩性胃炎证候要素包括气虚、湿、热、血瘀、气滞、阴虚、阳虚;两两证候要素中,气虚与气滞、气虚与阳虚、湿与热、血瘀与气滞、血瘀与阳虚、气滞与阳虚的关联性较高;湿、血瘀、气虚对重要病理改变异型增生的影响较大。[结论]对慢性萎缩性胃炎证候要素分布规律的研究可为进一步加深对慢性萎缩性胃炎的中医病因病机阐释提供参考。

[Objective]To discuss the distribution law of syndrome elements of chronic atrophic gastritis.[Methods]Clinical data of four traditional Chinese medicine(TCM)diagnosis,gastroscopy and pathological examination reports of patients with chronic atrophic gastritis were collected,and medical records database of chronic atrophic gastritis was established.Factor analysis,correspondence analysis and data mining methods like neural network modeling were used to analyze the distribution of syndromes of chronic atrophic gastritis,the correlation among syndromes and the correlation between important pathological changes and syndromes.[Result]The syndrome elements of chronic atrophic gastritis include qi deficiency,dampness,heat,blood stasis,qi stagnation,yin deficiency and yang deficiency.The correlation between qi deficiency and qi stagnation,qi deficiency and yang deficiency,dampness and heat,blood stasis and qi stagnation,blood stasis and yang deficiency,qi stagnation and yang deficiency was higher.[Conclusion]The study on the distribution law of chronic atrophic gastritis syndrome elements can provide reference for further deepening the explanation of etiology and pathogenesis of chronic atrophic gastritis in TCM.