羟氯喹联合红光治疗玫瑰痤疮的临床疗效观察

Clinical observation of hydroxychloroquine combined with red light in the treatment of acne rosacea

目的 探究羟氯喹联合红光治疗玫瑰痤疮的临床疗效。方法 90例玫瑰痤疮患者为研究对象,根据入院时间分为实验组和对照组,每组45例。对照组采用羟氯喹治疗,实验组采用羟氯喹联合红光治疗。对比两组患者治疗前后皮损评分、治疗效果、皮肤病生活质量指数(DLQI)评分、医院焦虑抑郁量表(HAD)评分及不良反应发生情况。结果 治疗后,实验组毛细血管扩张、红斑、瘙痒评分分别为(0.47±0.17)、(0.59±0.22)、(0.47±0.21)分,均低于对照组的(1.33±0.29)、(1.41±0.37)、(1.37±0.22)分,差异均有统计学意义(P<0.05)。实验组治疗总有效率91.11%高于对照组的60.00%,差异有统计学意义(P<0.05)。治疗后,实验组DLQI评分(2.52±0.63)分明显低于对照组的(7.11±1.25)分,差异有统计学意义(P<0.05)。治疗后,实验组HAD评分(4.59±1.17)分明显低于对照组的(15.66±1.51)分,差异有统计学意义(P<0.05)。实验组不良反应发生率6.67%明显低于对照组的24.44%,差异有统计学意义(P<0.05)。结论 玫瑰痤疮患者采用羟氯喹联合红光治疗疗效显著,对于缓解其临床症状有着积极的作用,还能够进一步提升其生活质量,安全性和有效性较高,值得应用和推广。

Objective To investigate the clinical efficacy of hydroxychloroquine combined with red light in the treatment of acne rosacea. Methods A total of 90 patients with acne rosacea were selected as the research subjects, and they were divided into an experimental group and a control group according to the time of admission,with 45 cases in each group. The control group was treated with hydroxychloroquine, and the experimental group was treated with hydroxychloroquine combined with red light. The skin lesion score before and after treatment,therapeutic effect, dermatology life quality index(DLQI) score and hospital anxiety and depression scale(HAD)score and occurrence of adverse reactions were compared between the two groups. Results After treatment, the scores of telangiectasia, erythema, and pruritus in the experimental group were(0.47±0.17),(0.59±0.22), and(0.47±0.21) points, which were lower than(1.33±0.29),(1.41±0.37), and(1.37±0.22) points in the control group,and the differences were all statistically significant(P<0.05). The total effective rate 91.11% in the experimental group was higher than 60.00% in the control group, and the difference was statistically significant(P<0.05). After treatment, the DLQI score(2.52±0.63) points of the experimental group was significantly lower than(7.11±1.25) points of the control group, and the difference was statistically significant(P<0.05). After treatment, the HAD score(4.59±1.17) points of the experimental group was significantly lower than(15.66±1.51) points of the control group, and the difference was statistically significant(P<0.05). The incidence of adverse reactions in the experimental group was 6.67%, which was significantly lower than 24.44% in the control group, and the difference was statistically significant(P<0.05). Conclusion Hydroxychloroquine combined with red light is effective in the treatment of acne rosacea patients, and has a positive effect on relieving their clinical symptoms. It can further improve their quality of life of patients with high safety and efficacy, and is worthy of application and promotion.