厄贝沙坦氢氯噻嗪在老年原发性高血压患者中的应用效果

Effect of Irbesartan Hydrochlorothiazide in Elderly Patients With Essential Hypertension

目的探讨厄贝沙坦氢氯噻嗪在老年原发性高血压(essential hypertension,EH)患者中的应用效果。方法选取2020年1月—2022年1月于福建省漳州市医院收治的共计80例老年EH患者,采用随机摸球法分成研究组(n=40)与对照组(n=40),对照组采用厄贝沙坦治疗,研究组采用厄贝沙坦氢氯噻嗪治疗,对两组患者的临床疗效、血压水平、心功能指标、生活质量及不良反应进行比较。结果研究组治疗总有效率(97.50%)较对照组(80.00%)明显更高;两组患者治疗后的舒张压(diastolic blood pressure,DBP)、收缩压(systolic blood pressure,SBP)均下降,研究组较对照组明显更低,差异均有统计学意义(P<0.05);两组患者治疗后的左心室射血分数(left ventricular ejection fraction,LVEF)明显提高,左心室后壁厚度(left ventricular posterior wall thickness,LVPW)、间隔舒张末期厚度(interventricularseptal thickness,IVS)明显降低,研究组LVEF较对照组明显更高,研究组LVPW、IVS较对照组明显更低,差异均有统计学意义(P<0.05);两组治患者治疗后生理功能、社会功能、精神活力水平均升高,研究组较对照组更高,差异均有统计学意义(P<0.05);研究组(5.00%)不良反应发生率较对照组(22.50%)明显更低,差异有统计学意义(P<0.05)。结论厄贝沙坦氢氯噻嗪应用到老年EH患者治疗中,可提高临床疗效,改善血压水平和心功能指标,提高生活质量,减少不良反应发生。

Objective To investigate the effect of irbesartan hydrochlorothiazide in elderly patients with essential hypertension(EH).Methods A total of 80 elderly EH patients admitted to Zhangzhou Municipal Hospital of Fujian Province from January 2020 to January 2022 were selected,and they were divided into the research group(n=40)and the control group(n=40)by random ball touch method.The control group was treated with irbesartan,and the research group was treated with irbesartan hydrochlorothiazide.The clinical efficacy,blood pressure,cardiac function index quality of life and adverse reactions of the two groups were compared.Results The total effective rate of the study group(97.50%)was significantly higher than that of the control group(80.00%).After treatment,the diastolic blood pressure(DBP)and systolic blood pressure(SBP)of the two groups decreased,and the study group was significantly lower than the control group,and the differences were statistically significant(P<0.05).Two groups after treatment in patients with left ventricular ejection fraction(LVEF),left ventricular posterior wall thickness,(LVPW)and interventricularseptal thickness(IVS)were significantly decreased,LVEF in the study group was significantly higher than that in the control group,LVPW and IVS in the study group were significantly lower than those in the control group,the differences were statistically significant(P<0.05).After treatment,the levels of physiological function,social function and mental vitality of the two groups were increased,and the study group was higher than the control group,and the differences were statistically significant(P<0.05).The incidence of adverse reactions in the study group(5.00%)was significantly lower than that in the control group(22.50%),and the difference was statistically significant(P<0.05).Conclusion Application of irbesartan hydrochlorothiazide in the treatment of elderly EH patients can improve clinical efficacy,improve blood pressure level and cardiac function indicators,improve the quality of life and reduce the incidence of adverse reactions.