血清25-羟维生素D_(3)、甲状腺过氧化物酶抗体及抗心磷脂抗体与子痫前期的关系研究

Study on the relationship between serum 25-hydroxyvitamin D_(3),thyroid peroxidase antibody,anticardiolipin antibodies and preeclampsia

目的探究血清25-羟维生素D_(3)、甲状腺过氧化物酶抗体和抗心磷脂抗体与子痫前期的相关性。方法选取2019年1月至2021年12月在佛山市高明区人民医院进行规律产检并生产的120名孕妇作为研究对象,按照患病情况分为子痫前期组(n=60)和正常对照组(n=60)。比较两组孕妇的血清25-羟维生素D_(3)含量、甲状腺过氧化物酶抗体、抗心磷脂抗体阳性率。结果子痫前期组的血清25-羟维生素D_(3)水平显著低于对照组,而甲状腺过氧化物酶抗体、抗心磷脂抗体阳性率显著高于对照组,差异均有统计学意义(P<0.05);子痫前期组发生不良结局的概率高于正常对照组,差异有统计学意义(P<0.05);Logistic回归分析提示,25-羟维生素D_(3)<30ng/ml、甲状腺过氧化物酶抗体阳性、抗心磷脂抗体阳性及年龄是子痫前期发生的危险因素(P<0.05)。结论维生素D的缺乏、高水平的甲状腺过氧化物酶抗体及抗心磷脂抗体与子痫前期的发生相关,孕检一旦发现要及时提防子痫前期的发生,降低不良妊娠结局的概率。

Objective To explore the correlation of serum 25-hydroxyvitamin D_(3),thyroid peroxidase antibody and anticardiolipin antibody with preeclampsia.Methods A total of 120 pregnant women who underwent regular obstetric examinations and gave birth at the People's Hospital of Gaoming District,Foshan City from January 2019 to December 2021 were selected and divided into the preeclampsia group(n=60)and the normal control group(n=60)according to their disease status.Compared the serum 25-hydroxyvitamin D_(3)levels,thyroid peroxidase antibodies and anti-cardiolipin antibodies positive rates in the two groups of pregnant women.Results Serum 25-hydroxyvitamin D_(3)level was significantly lower in the preeclampsia group than that in the control group,while the positive rates of thyroid peroxidase antibodies and anticardiolipin antibodies were significantly higher than those in the control group,with statistically significant differences(P<0.05);and the probability of adverse outcomes was higher in the preeclampsia group than that in the normal control group,with statistically significant differences(P<0.05).Logistic regression analysis showed that 25-hydroxyvitamin D_(3)less than 30ng/ml,positive thyroid peroxidase antibody,positive anticardiolipin antibody and age were the risk factors for the occurrence of preeclampsia(P<0.05).Conclusion Vitamin D deficiency,high levels of thyroid peroxidase antibodies and anticardiolipin antibodies are associated with preeclampsia,and if they are found in the pregnancy test,it is necessary to guard against the occurrence of preeclampsia in time to reduce the probability of adverse pregnancy outcomes.