人乳头瘤病毒感染与治疗研究进展

Advances in human papillomavirus infection and treatment

高危型人乳头瘤病毒(HPV)持续感染是宫颈癌前病变和浸润癌的高危因素。HPV疫苗已在全球应用十余年,对阻断HPV感染和减少宫颈癌的发生发挥了巨大作用,但HPV疫苗接种和宫颈癌筛查在很多国家或地区并未完全普及;此外,疫苗的非全覆盖和非完全有效使宫颈癌仍存在一定的发生风险。因此,除了HPV疫苗接种和三阶梯筛查,对错失疫苗保护先机及已行宫颈癌疫苗注射后仍感染HPV的患者积极进行干预,是预防宫颈癌发生的重要环节。鉴于此,本文拟从HPV干预的角度,对目前各种HPV干预方法进行综述,以期为HPV感染、尤其是持续性HPV感染的临床治疗提供参考。

Persistent infection of high-risk human papillomavirus(HPV)is a high risk factor for cervical precancerous lesion and invasive carcinoma.HPV vaccine has been used in the world for more than 10 years,which has played a great role in blocking HPV infection and reducing the incidence of cervical cancer;however,HPV vaccination and cervical cancer screening have not been fully popularized in many countries or regions;in addition,the incomplete coverage and incomplete effectiveness of the vaccine still have a certain risk of cervical cancer.Therefore,besides HPV vaccination and three-step screening,active intervention is an important link to prevent cervical cancer for these patients who missed the opportunity of vaccine protection or still infected with HPV after cervical cancer vaccine injection.Given the above current situation,this article intends to review various current HPV intervention methods from the perspective of HPV intervention,in order to provide reference on the clinical treatment of HPV infection,especially persistent HPV infection.