肠道菌群与脂质吸收及其调控

Roles of Gut Microbiota in Regulating Intestinal Lipid Absorption

肠道菌群(gut microbiota)在维持宿主脂质代谢稳态过程中发挥着关键调节作用。肠道菌群能协助并增强宿主对食物中多糖的消化,促进肠道上皮细胞对长链脂肪酸的吸收,调节脂肪组织的功能。因此肠道菌群紊乱将严重影响宿主脂质代谢平衡,并诱发肥胖、高脂血症、脂肪肝等一系列脂代谢疾病。本文从肠道菌群调控肠道上皮细胞脂质吸收的角度对已知的调控机制进行综述。

Gut microbiota plays a key role in regulating mammalian metabolic homeostasis. Resident intestinal bacteria enhance digestion of dietary polysaccharides, promote dietary lipid absorption by intestinal epithelial cells, and regulate the function of adipose tissue. Therefore, dysregulated gut microbiota is inclined to induce a series of metabolic disorders, such as obesity, hyperlipidemia and fatty liver disease, etc. This review summarizes the regulatory mechanisms by which the gut microbiota promotes epithelial absorption of dietary lipids.