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细胞焦亡在脑出血中的作用 被引量:2

The Role of Pyroptosis in Intracerebral Hemorrhage
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摘要 脑出血后的神经损伤涉及多种病理过程及机制。近年来研究发现,脑出血后血肿周围组织出现细胞焦亡(pyroptosis),而抑制细胞焦亡能减轻神经损伤,对脑组织起保护作用。因此,细胞焦亡可能是脑出血的潜在干预靶点。进一步研究细胞焦亡在脑出血患者神经修复中的作用,可以为脑出血的治疗提供新的思路。本文就细胞焦亡在脑出血中的研究进展进行综述,旨在为相关领域的研究提供参考。
作者 郭亚净 王洪 GUO Ya-Jing;WANG Hong
出处 《生理科学进展》 CAS 2022年第6期458-462,共5页 Progress in Physiological Sciences
基金 河北中医学院科研能力提升项目(KTY2019053) 河北中医学院优秀青年教师基础研究计划项目(YQ2019005)资助课题。
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  • 1Godoy DA, Pinero G, Di Napoli M. Predicting mortality in spontaneous intra- cerebral hemorrhage: can modification to original score improve the predic- tion? Stroke. 2006;37:1038-1044.
  • 2van Asch CJ, Luitse M], Rinkel GJ, et al. Incidence, case fatality, and functional outcome of intracerebral haemorrhage over time, according to age, sex, and ethnic origin: a systematic review and meta-analysis. Lancet Neurol. 2010;9: 167 176.
  • 3Wang JA, Dore S. Heine oxygenase-I exacerbates early brain injury after intracerebral haemorrhage. Brain. 2007; 130:1643-1652.
  • 4Chen G, Shaw MH, Kim YG, et al. NOD-like receptors: role in innate immunity and inflammatory disease. Annu Rev Pathol Mech. 2009;4:365 398.
  • 5Tschopp J, Schroder K. NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production? Nat Rev ImmunoL 2010; 10: 210-215.
  • 6Kaindl AM, Degos V, Peineau S, et al. Activation of microglial N-methyl-D- aspartate receptors triggers inflammation and neuronal cell death in the developing and mature brain. Ann NeuroL 2012;72:536-549.
  • 7Lin S, Yin Q, Zhong Q, et al. Heine activates TLR4-mediated inflammatory injury via MyD88JTRIF signaling pathway in intracerebral hemorrhage. J Neuroinflammation. 2012;9:46.
  • 8Cai Y, Cho GS, Ju C, et al. Activated microglia are less vulnerable to hemin toxicity due to nitric oxide-dependent inhibition of JNK and p38 MAPK acti- vation. J lmrnunol. 2011 ;187:1314-1321.
  • 9Aronowski J, Hall CE. New horizons for primary intracerebral hemorrhage treatment: experience from preclinical studies. Neurol Res. 2005;27: 268-279.
  • 10Morgenstern LB, Hemphill 3rd JC, Anderson C, et al. Guidelines for the man- agement of spontaneous intracerebral hemorrhage: a guideline for healthcare professionals from the American Heart AssociationJAmerican Stroke Associa- tion. Stroke. 2010;41:2108-2129.

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