摘要
目的探究盐酸多奈哌齐治疗轻中度血管性痴呆患者的临床价值。方法84例轻中度血管性痴呆患者,采用随机双盲法分为对照组及观察组,各42例。对照组给予尼麦角林治疗,观察组给予盐酸多奈哌齐治疗。比较两组患者临床疗效,长谷川痴呆量表(HDS)、简易精神状态检查量表(MMSE)、日常生活能力量表(ADL)评分及不良反应发生情况。结果观察组患者HDS、MMSE、ADL评分分别为(25.16±3.61)、(25.60±3.35)、(67.36±4.26)分,均高于对照组的(21.94±4.06)、(18.03±4.23)、(60.06±5.33)分,差异有统计学意义(P<0.05)。观察组患者治疗总有效率92.86%高于对照组的71.43%,差异有统计学意义(P<0.05)。观察组患者用药期间不良反应发生率为11.90%,与对照组的14.29%比较,差异无统计学意义(P>0.05)。结论为轻中度血管性痴呆患者应用盐酸多奈哌齐干预,无论是病情疗效或者药物安全性风险都满足临床预期,帮助患者更好的回归到正常生活。
Objective To investigate the clinical value of donepezil hydrochloride in patients with mild to moderate vascular dementia.Methods A total of 84 patients with mild to moderate vascular dementia were randomly divided into control group and observation group by double-blind method,with 42 cases in each group.The control group was treated with nicergoline,and the observation group was treated with donepezil hydrochloride.The clinical efficacy,Hasegawa Dementia Scale(HDS)score,Mini-Mental State Examination(MMSE)score,Activities of Daily Living(ADL)score,and occurrence of adverse reactions were compared between the two groups.Results The HDS,MMSE and ADL scores of the observation group were(25.16±3.61),(25.60±3.35)and(67.36±4.26)points,which were higher than(21.94±4.06),(18.03±4.23)and(60.06±5.33)points of the control group,and the differences were all statistically significant(P<0.05).The total effective rate 92.86%in the observation group was higher than 71.43%in the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group during medication was 11.90%,and the difference was not statistically significant compared with 14.29%in the control group(P>0.05).Conclusion The application of donepezil hydrochloride in the treatment of mild to moderate vascular dementia patients can meet the clinical expectations in terms of the efficacy of the disease or the risk of drug safety,and help the patients better return to normal life.
作者
吴灵莉
WU Ling-li(Pharmacy Department,Wuyishan Municipal Hospital,Wuyishan 354300,China)
出处
《中国现代药物应用》
2022年第21期119-121,共3页
Chinese Journal of Modern Drug Application
关键词
轻中度血管性痴呆
盐酸多奈哌齐
疗效
不良反应
Mild to moderate vascular dementia
Donepezil hydrochloride
Efficacy
Adverse reactions