慢性胃炎证素分布特点与血清胃泌素水平相关性研究

Study on the Correlation between Distribution Characteristics of Chronic Gastritis Syndrome Elements and Serum Gastrin Levels

目的探讨慢性胃炎的证素分布特点及与血清胃泌素水平的相关性,以期为本病的临床病证诊断及疗效评价提供客观手段。方法以96例慢性胃炎患者为研究对象,采集四诊资料并检测血清胃泌素水平,采用证素辨证方法分析慢性胃炎的证素分布规律,并研究胃泌素水平差异,分析其与证素、病性兼杂特征的关系。结果慢性胃炎的病性证素分布以气滞、湿、气虚、阳虚、热多见,病位证素分布以胃、脾、肝多见,气滞易与其他病性证素兼具。慢性胃炎胃泌素水平明显高于健康体检者。慢性胃炎的胃泌素水平肝组高于胃组,阳虚组高于气滞、湿、血瘀组。慢性胃炎胃、脾、肝、气滞、气虚、阳虚、阴虚组胃泌素水平均明显高于健康体检者。湿、热组胃泌素水平高于健康体检者。结论慢性胃炎患者的证素分布特点符合临床分布实际情况,能够更好规范临床辨证;检测血清胃泌素水平对本病的诊断有一定的指导意义,可为本病的中医疗效评价提供客观依据。

Objective To explore the distribution characteristics of syndrome elements in patients with chronic gastritis and their correlation with serum gastrin levels,so as to provide objective method for clinical syndrome diagnosis and curative effect evaluation based on expectation.Methods 96 patients with chronic gastritis were studied,four diagnosis data were collected and serum gastrin levels were measured,the distribution of syndrome elements and gastrin levels in chronic gastritis were analyzed by syndrome differentiation method,and the relationship between the changes of syndrome elements,disease and mixed disease features was analyzed.Results The pathogenic factors of chronic gastritis are mostly qi stagnation,dampness,qi deficiency,yang deficiency and heat,and the disease location syndrome factors are more common in stomach,spleen and liver.Qi stagnation is easy to combine with other disease syndromes.The level of Gastrin inpatients with chronic gastritis were significantly higher than those in healthy examination peoples.The level of gastrin with chronic gastritis was significantly higher in liver group than in stomach group.In patients with chronic gastritis,the gastrin level of the disease syndrome element in the yang deficiency group is higher than that in the qi stagnation,dampness and blood stasis groups.The gastrin levels in the stomach,spleen,liver,qi stagnation,qi deficiency,yang deficiency,and yin deficiency groups of chronic gastritis were significantly higher than those in the healthy examination peoples,the gastrin levels in the damp groups,heat groups were higher than those in the healthy examination peoples.Conciusion The distribution characteristics of syndrome elements in patients with chronic gastritis are consistent with the actual clinical distribution,which can better standardize the clinical syndrome differentiation.Detection of serum gastrin level has certain guiding significance for the diagnosis of this disease and can provide objective basis for the evaluation of the curative effect of traditional Chinese medicine.