阿尔茨海默病外周血生物标志物的临床应用前景

Clinical application prospect of biomarkers in peripheral blood of alzheimer's disease

阿尔茨海默病(Alzheimer's Disease,AD)是最常见的神经变性疾病,发病机制尚未完全阐明。AD伴发早期识别及恰当的干预仍有较大难度,急需易于获取且经济、有效的生物标志物来提高临床诊疗水平。近年来,AD外周血生物标志物发展蓬勃,可能在未来彻底改变AD的诊疗现状。本文就AD外周血生物标志物新进展及如何应用于临床实践进行讨论。

Alzheimer's Disease(AD)is a common neurodegenerative disease,but the exact pathogenesis is still under investigation.Therefore,it is difficult to early identify and make the appropriate intervention.Easily available,economical,and effective biomarkers are urgently needed to improve clinical diagnosis and treatment.In recent years,the development of blood-based biomarkers in AD has developed vigorously,and it may be able to completely change the status of the diagnosis and treatment of AD in the near future.Here we presents an overview of the latest advances in the blood-based biomarkers of AD and its potential clinical implementation.