非典型快速进展的认知障碍1例报道

A case of atypical rapidly progressive cognitive impairment

目的:快速进展性痴呆(rapid progressive dementia,RPD)是一类进展快速的痴呆综合征,通过分析回顾不典型快速进展的认知障碍患者的临床表现,探讨造成该类病例容易误诊的原因。方法:收集1例于2021年11月17日在我院收治的疑似RPD患者的详细病史,结合症状、体征、系列评价量表、头颅MR等辅助检查结果,通过与国内外RPD诊断标准和文献比较,回顾分析诊断的可靠性。结果:该例快速进展的认知障碍诊断值得商榷,其原因复杂。结论:认知障碍患者的就诊,医生尤其需要关注对照料者和知情者问诊的重要性。

Objective:Rapid progressive dementia(RPD)is a kind of dementia syndrome with rapid progress.This paper reports a case of atypical cognitive impairment with rapid progress and discuss the reasons for the misdiagnosis of this type of cases.Methods:The diagnosis and treatment of a suspected RPD patient admitted to our hospital on November 17,2021 were analyzed,and the related research progress was reviewed.The reliability of the diagnosis was retrospectively analyzed by comparing with domestic and international diagnostic criteria as well as literature for RPD,combined with symptoms,signs,a series of neuropsychological scales,cranial MR and other auxiliary examination results.Results:The diagnosis of rapidly progressive cognitive impairment in this case is questionable and has complex causes.Conclusion:The importance of consultation with caregivers and informed persons is of particular concern to physicians in the consultation of patients with cognitive impairment.