癫痫潜在相关生物学标志物研究进展

Research advances in the potential relevant biomarkers of epilepsy

癫痫发病机制复杂,病理改变呈多样化,随着分子生物学及细胞水平研究技术的进步,癫痫的病生机制将逐步明朗。微小RNA(MiRNAs)、淋巴细胞、凋亡蛋白、炎性因子等在癫痫发生发展过程中变化显著,表现出对疾病潜在的诊治价值。明确这些潜在生物学标志物与癫痫的确切联系,有望在临床开展应用,并助力治疗策略的制定。

The pathogenesis of epilepsy is complex and the pathological changes are diversified.With the progress in the researches on molecular biology and research technologies at cellular level,the pathogenic mechanism of epilepsy will gradually become clear.MiRNAs(microRNA),leukomonocyte,apoptotic proteins,and inflammatory factors change significantly during the development of epi‐lepsy,and show a potential value for the diagnosis and treatment of the disease.Clarifying the exact link of these potential biomarkers to epilepsy is expected to apply them clinically and contributes to working out therapeutic strategies.