老年高血压相关性衰弱的发病机制及运动干预机制的研究进展

Recent Advances in Pathogenesis and Mechanism of Action of Exercise Regarding Frailty in Older Adults with Hypertension

随着我国老龄化进程的进一步加剧,衰弱作为常见的老年综合征已成为备受关注的公共卫生问题。高血压与衰弱常共存于老年人,导致出现多种不良健康结局。本文分析了老年高血压相关性衰弱的流行现状及发病机制,包括炎性反应、氧化应激反应、胰岛素抵抗及激素代谢紊乱等,总结了运动干预改善高血压相关性衰弱的可能作用途径,并发现目前关于高血压相关性衰弱的运动作用机制类研究仍然缺乏,而且不同类型的运动干预形式对机体的作用机制也存在一定差异性,未来可以进一步探讨不同的运动干预形式对高血压相关性衰弱的作用靶点及干预效果的不同。

Frailty is a common geriatric syndrome that has become a great public health concern in China with the acceleration of population aging.Hypertension and frailty often coexist in older adults,leading to multiple adverse health outcomes.We reviewed recent advances in epidemiology of frailty in older people with hypertension,and its pathogenesis involving inflammatory response,oxidative stress,insulin resistance and hormone metabolism,and the possible mechanisms of action of exercise in improving it,then summarized that relevant studies on mechanisms of action of exercise in enhancing frailty in older people with hypertension are still insufficient,and the mechanism of action varies by the type of exercise.Further research could explore the targets and effects of different types of exercise in improving frailty in older people with hypertension.