阿尔茨海默病韧性的遗传机制及其临床应用的前景

Genetic mechanism underlying the resilience to Alzheimer's disease and its prospect for clinical application

阿尔茨海默病(Alzheimer′s disease,AD)是一种以进行性认知障碍为主要临床特征的神经退行性疾病,也带来了全球老年人的重大健康问题和社会问题。除致病机制外,深入研究AD的保护性机制对实现对因治疗同样重要。AD韧性是一种能够抵御AD遗传风险或病理改变所致认知障碍的保护性机制。针对AD韧性遗传机制的探索对于揭示新型AD保护性机制、寻找干预靶点,以及优化遗传风险预测模型、早期识别AD高危人群并指导干预措施具有重要的意义。

As the most common neurodegenerative disease,Alzheimer's disease(AD)is characterized by progressive cognitive decline and is a major threat to the health of elderly worldwide.Aside from its pathogenesis,delineation of the protective mechanism of AD is also critical for the etiological treatment.AD resilience refers to a protective mechanism which can maintain the cognitive intactness of patients,despite of genetic risk factors and/or related pathology.Studies on the genetic mechanism of AD resilience are of great importance for revealing novel mechanisms and therapeutic targets,as well as optimizing polygenetic risk score which can facilitate early identification and intervention for individuals at risk.