血管生成素在糖尿病视网膜病变中的研究现状和进展

The present research and progress of angiopoietin in diabetic retinopathy

糖尿病视网膜病变(DR)是糖尿病最常见的微血管并发症之一,是糖尿病患者视力丧失的主要原因。血管生成素(Ang)是一类分泌蛋白的超家族,是调节血管内环境稳定、参与血管生成和修复、脂质代谢的血管生长因子,在DR发生发展中起重要作用,已经成为目前治疗DR的一个新靶点。随着对Ang研究的深入以及各种针对Ang药物的研发,未来有望为DR的治疗带来新的观点和策略。

Diabetic retinopathy(DR)is one of the most common microvascular complications of diabetes,and it is the main cause of vision loss in diabetic patients.Angiopoietin(Ang),a superfamily of secreted proteins,is a vascular growth factor that regulates the stability of vascular environment,participates in angiogenesis and repair,and lipid metabolism.It plays an important role in the development of DR and has become a new target for the treatment of diabetic retinopathy.With the in-depth study of Ang and the research and development of various drugs for Ang,it is expected to bring new ideas and strategies for the treatment of DR in the future.