阻塞性睡眠呼吸暂停综合征应用持续气道正压通气疗效分析

Analysis on the effect of continuous positive airway pressure ventilation on obstructive sleep apnea syndrome

目的对比研究临床诊断OSAHS患者,接受CPAP治疗对心脑血管事件发生率的影响。方法连续纳入422例OSAHS患者。随访1年,记录患者的主要不良心脑血管事件的发生情况。结果K-M生存分析发现,CPAP并不能改善中重度患者的MACCE发生风险(P>0.05)。多因素COX回归分析显示合并冠心病、心律失常是OSAHS患者MACCE的独立危险因素。结论CPAP治疗可改善OSAHS患者的AHI指数,合并冠心病、心律失常的OSAHS患者发生MACCE的风险高于无冠心病、心律失常的OSAHS患者。年龄可作为OSAHS患者MACCE发生的预测因素。

Objective To compare and study the effect of clinical diagnosis of OSAHS and CPAP therapy on the incidence of cardiovascular and cerebrovascular events.Methods A total of 422 patients with OSAHS were consecutively enrolled.The patients were followed up for 1 year to record the occurrence of major adverse cardiovascular and cerebrovascular events.Results K-M survival analysis found that CPAP did not improve the risk of MACCE in moderate-to-severe patients(P>0.05).Multi-factor COX regression analysis showed that coronary heart disease and arrhythmia were independent risk factors for MACCE in OSAHS patients.Conclusions CPAP treatment can improve the AHI index of OSAHS patients.OSAHS patients with coronary heart disease and arrhythmia have a higher risk of MACCE than OSAHS patients without coronary heart disease and arrhythmia.Age can be used as a predictive factor of MACCE in OSAHS patients.