三黄泻心汤颗粒治疗湿热蕴结证非酒精性脂肪性肝病的临床疗效

Observation of San-Huang-Xie-Xin-Tang decoction in treating non-alcoholic fatty liver disease with damp-heat accumulation syndrome

目的:研究三黄泻心汤颗粒治疗湿热蕴结证非酒精性脂肪性肝病(NAFLD)患者的临床疗效。方法:将66例NAFLD患者分为对照组和治疗组,每组33例,对照组口服多烯磷脂酰胆碱;治疗组患者在对照组基础上给予三黄泻心汤颗粒剂,疗程均为3个月,观察分析两组患者的临床疗效、中医症状改善情况及治疗前后肝功能及血脂水平和B超变化,并观察不良反应。结果:治疗组患者有效率为93.94%(31/33),对照组为63.64%(21/33),差异有统计学意义(P<0.05)。与对照组患者相比,治疗组患者中医症状(右胁胀痛、胸脘痞满、周身困顿)改善比例明显高于对照组(P<0.05);同时治疗组患者丙氨酸氨基转移酶、甘油三酯及胆固醇下降水平明显高于对照组(P<0.05);B超提示,治疗组患者中重度脂肪肝比例明显减少(P<0.05);两组患者不良反应发生率差异无统计学意义(P>0.05)。结论:三黄泻心汤颗粒治疗湿热蕴结证NAFLD患者疗效显著。

Objective:To study the clinical efficacy of San-Huang-Xie-Xin-Tang decoction in the treatment of NAFLD patients with damp-heat accumulation syndrome.Methods:70 NAFLD patients were divided into control group and study group.The control group was given polyene phosphatidylcholine and the treatment group was given San-Huang-Xie-Xin-Tang decoction on the basis of the control group.The course of treatment lasted for 3 months.The clinical efficacy,improvement of TCM symptoms,changes of liver function,blood lipid level,B-ultrasound and adverse reactions were recorded.Results:The effective rate was 93.93%(31/33)in the treatment group and 63.64%(21/33)in the control group.The difference between the two groups was statistically significant(P<0.05).Compared with the control group,the proportion of TCM symptoms(right hypochondriac pain,full chest cavity,and drowsiness)was significantly improved in the treatment group than in the control group(P<0.05).The decrease in valuealanine aminotransferase,triglyceride and cholesterol of the patients in the treatment group was significantly higher than that of the control group(P<0.05).B-ultrasound indicated that the proportion of moderate and severe fatty liver in the treatment group was significantly reduced(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:San-Huang-Xie-Xin-Tang decoction is effective in treating NAFLD patients with damp-heat accumulation syndrome.