小儿慢性胃炎合并幽门螺旋杆菌感染的影响因素分析

Analysis of influencing factors of chronic gastritis complicated with Helicobacter pylori infection in children

目的:探讨小儿慢性胃炎合并幽门螺旋杆菌(Hp)感染的影响因素。方法:回顾性分析2020年1月至2022年4月本院收治的113例慢性胃炎患儿的临床资料,根据Hp感染检测结果分为Hp阳性组(n=61)与Hp阴性组(n=52)。比较两组患儿胃镜检查结果、病理组织学特点。采用多因素Logistic回归分析慢性胃炎患者合并Hp的影响因素。结果:两组患儿均以糜烂出血性慢性胃炎和结节性慢性胃炎为主要表现,部分合并胆汁反流,未发现有慢性萎缩性胃炎。Hp阳性组患儿糜烂出血性慢性胃炎的发生率低于Hp阴性组,结节性慢性胃炎的发生率高于Hp阴性组(均P<0.05)。Hp阳性组患儿淋巴滤泡阳性,中、重度炎症活动,中、重度黏膜病变的发生率均高于Hp阴性组(均P<0.05)。多因素Logistic回归分析结果显示,父母受教育程度低、有吸吮手指或玩具、有咀嚼喂养、无饭前或便后洗手、无专用餐具均为慢性胃炎患儿合并Hp感染的独立危险因素(均P<0.05)。结论:合并Hp感染的慢性胃炎患儿多为结节性慢性胃炎,父母受教育程度低和不良卫生习惯为小儿慢性胃炎合并Hp感染的危险因素。

Objective:To explore the influencing factors of chronic gastritis complicated with Helicobacter pylori(Hp)infection in children.Methods:A total of 113 children with chronic gastritis admitted to our hospital from January 2020 to April 2022 were retrospectively selected.According to the detection results of Hp infection,they were divided into Hp-positive group(n=61)and Hp-negative group(n=52).The results of gastroscopy and histopathological characteristics were compared between the two groups,and multivariate Logistic regression analysis was used to analyze the influencing factors of chronic gastritis patients complicated with Hp.Results:Erosive hemorrhagic chronic gastritis and nodular chronic gastritis were the main manifestations in the two groups of children,some of whom were combined with bile reflux,and no chronic atrophic gastritis was found.The incidence of erosive hemorrhagic chronic gastritis of Hp-positive group was lower than that of Hp-negative group,and the incidence of nodular chronic gastritis was higher than that of Hp-negative group(all P<0.05).The incidence of positive lymphoid follicles,moderate-to-severe inflammatory activity,and moderate-to-severe mucosal lesions in children with chronic gastritis in the Hp-positive group were higher than those in the Hp-negative group(all P<0.05).The results of multivariate Logistic regression analysis showed that parents with low educational level,sucking fingers or toys,chewing feeding,without washing hands before meals or after defecation and no special tableware were independent risk factors for children with chronic gastritis complicated with Hp infection(all P<0.05).Conclusion:Children with chronic gastritis complicated with Hp infection are mostly those with nodular chronic gastritis and low education level of their parents as well as poor hygiene habits are risk factors for chronic gastritis complicated with Hp infection in children.