基质辅助激光解析电离飞行时间质谱分析合成聚合物样品制备的研究进展

Progress on Sample Preparation of Synthetic Polymers Analysis by Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry

基质辅助激光解析电离飞行时间质谱(MALDI-TOF-MS)在合成聚合物的表征手段中具有不可替代的优点,可以提供聚合物的质量分布、嵌段长度、端基等信息.但由于合成聚合物的离子化效率通常不佳,因此样品制备是分析成功的关键.从基质、基质添加剂以及混样方式3个方面综述了MALDI-TOF质谱分析合成聚合物样品制备的研究进展.

Matrix-assisted laser desorption ionization time-of-flight mass spectrometry(MALDI-TOF-MS)has irreplaceable advantages in the characterization of synthetic polymers,and provides information on the mass distribution,block length and end groups of polymers.However,sample preparation is critical for successful analysis because of the poor ionization efficiency of synthetic polymers.The research progress on sample preparation of synthetic polymers analyzed by MALDI-TOF was reviewed from three aspects:matrix,matrix additives and sample mixing methods.