1~6岁儿童25羟维生素D与血红蛋白关系的横断面研究

A cross-sectional study on the association between 25-hydroxy vitamin D and hemoglobin in children aged 1-6 years old

目的通过分析美国国家健康与营养监测调查数据库(NHANES)儿童25羟维生素D[25(OH)D]与血红蛋白(Hgb)的关系,为预防儿童贫血提供参考。方法选取NHANES 2015—2018年1591例1~6岁儿童纳入横断面研究。采用加权多元线性回归分析25(OH)D与Hgb的关系。结果1~6岁儿童Hgb为(124.71±8.08)g/L,贫血51例(3.21%);25(OH)D为(69.73±18.17)nmol/L,缺乏症19例(1.19%)。贫血发生率随年龄增长逐渐降低(χ^(2)=15.662,P<0.001)。多元线性回归分析,25(OH)D与Hgb呈正相关[β=0.045,95%CI(0.023,0.066),P<0.05]。结论1~6岁儿童25(OH)D与Hgb存在正相关趋势,儿童年龄、母亲生育年龄、季节为协同因素。

Objective To analyze the association between 25-hydroxy vitamin D[25(OH)D]and hemoglobin(Hgb)in children from the National Health and Nutrition Surveillance Survey(NHANES)database,and to provide reference for the prevention of anemia in children.Methods A total of 1591 children aged 1-6 years old from 2015 to 2018 in NHANES were included in this cross-sectional analysis.The association between 25(OH)D and Hgb was analyzed by weighted multi-variable linear regression model.Results The Hgb of children aged 1-6 years old was(124.71±8.08)g/L,the incidence of anemia was 3.21%(51 cases).The 25(OH)D was(69.73±18.17)nmol/L,the prevalence of 25(OH)D deficiency was 1.19%.The prevalence of anemia gradually decreased with age(χ^(2)=15.662,P<0.001).The multiple linear regression analysis showed that 25(OH)D was positively correlated with Hgb[β=0.045,95%CI(0.023,0.066),P<0.05].Conclusion This study suggests that 25(OH)D level is positively correlated with Hgb in children aged 1-6 years old,and there are synergistic effects with children’s age,mother’s childbearing age and seasons.