稀有糖类益生元研究进展

Research Progress of Rare Carbohydrate Prebiotics

活性稀有糖是一类有特殊化学结构、具有调节肠道菌群平衡、抑制病原菌发酵、抗氧化、增强免疫力、抗肿瘤等多种生物活性的益生元;活性稀有糖作为健康食品的生产原料,被广泛应用于保健食品、婴幼儿配方食品、乳制品、功能饮料等的生产。近年来,活性稀有糖的相关研究越来越受到人们的重视,在新型活性稀有糖挖掘、结构解析、提取工艺优化、稀有糖生物发酵或生物合成以及生物活性拓展及机制研究等方面取得了系列进展。本文对这些进展进行了回顾和展望,重点总结了活性稀有糖类的结构、生物活性、生物转化研究进展并就其工业化应用、现存问题和解决办法进行了探讨,为新型活性稀有糖的开发、功能挖掘及产业化生产利用提供理论依据。

Rare sugars are a kind of prebiotics with special chemical structure and bioactivities such as regulate intestinal flora,inhibit pathogen,resist oxidation,improve immunity,antitumor and so on.Rare sugars were widely used in the production of health food,infant formula food,dairy products as well as functional drinks.Nowadays,series progress has been made in the discovering of novel rare sugar,structural analysis,optimization of producing process,enzyme engineering,metabolic engineering and Izumoring strategy research.This paper reviews and prospects above advances,focuses on the research progress of bioactivity and biotransformation of rare sugars,and discusses their industrial application potential,existing problems and solutions,to provide a theoretical basis for the development,function mining and industrial production and utilization of rare sugars.