摘要
Aim:Choroidal metastases are rare in the evolution of solid cancers and constitute exceptional metastatic sites involving functional visual prognosis.The authors conducted a retrospective study to determine the interest of external radiotherapy for the treatment of choroidal metastases.Methods:The authors reviewed the records of 28 patients with choroidal metastases who had breast(n=15),lung(n=9),ovarian(n=1),kidney(n=1),prostate(n=1)cancer or carcinoma with unknown primitive at the moment of the diagnosis(n=1).The median age was 58 years(extremes:34-71 years).Tumor stage before the discovery of metastatic choroidal metastasis was 50%of patients.Ocular involvement was unilateral(n=22)or bilateral(n=6).The delivered doses ranged from 20 to 50 Gy fractionated with 3-5 Gy in 2D technique(n=5),conformational(n=21),intensity modulation(n=2).The most widely used prescription scheme delivered 30 Gy in 10 fractions(64%)using two 6 MV photons beams.Results:At the end of irradiation,13 patients(46%)showed an improvement of eye symptoms.For the others,a stabilization in symptoms was noted(n=15).No patient had visual degradation.No acute or late grade 2-3 toxicities were objectified.The histological type did not influence the response(P=0.5).There was no dose relationship-response in our series.Conclusion:External radiation therapy is a useful technique in the palliative treatment of choroidal metastases.Acute and late toxicities are acceptable.
