摘要
In the review“Role of adenosine in tumor progression:focus on A2B receptor as potential therapeutic target”,Sorrentino and Morello make a compelling case for considering adenosine 2B receptor(A2BR)as a target in cancer therapy(J Cancer Metastasis Treat 2017;3:127-38).A large body of evidence has accumulated suggesting A2BR to play an active role in tumor immune suppression and metastasis.Thus,this commentary will discuss the intriguing possibility of targeting A2BR in specific breast cancers that express high levels of A2BR and attract infiltrating immune cells.
