摘要
在N-甲基吡咯烷酮的促进下,肉桂酸与草酰氯在10℃酰氯化反应1 h后,再与加入的胺在35℃酰胺化反应4 h得到目标化合物N-肉桂酰胺;目标化合物结构经(1)^H NMR、(13)^C NMR,IR和EI-MS等表征;同时提出了NMP促进反应的可能机理。该方法具有反应条件温和、操作简便和反应时间短等优点。
Compounds N-cinnamamide were synthesized through the reaction of cinnamic acid with oxalyl chloride at 10℃for 1 h using N-methyl pyrrolidone as the reactive promotor,followed by amidation with amine at 35℃for 4 h.The title compounds were characterized by(1)^H NMR,(13)^C NMR,IR and EI-MS.A mechanism for the NMP promoting reaction of cinnamic acid with amine was put forward.The main advantages of the developed methodology were under mild reaction conditions,simple work-up procedure and short reaction time.
作者
祝显虹
温小洪
毛刘量
周安西
ZHU Xian-hong;WENG Xiao-hong;MAO Liu-liang;ZHOU An-xi(Key Laboratory of Applied Organic Chemistry,Higher Institutions of Jiangxi Province,Shangrao Normal University,Shangrao 334001,China)
出处
《化学研究与应用》
CAS
CSCD
北大核心
2022年第12期2983-2987,共5页
Chemical Research and Application
基金
江西省教育厅科技项目(201721)资助
上饶师范学院科研项目(201947)资助
上饶市基础应用研究项目(SKB2021018)资助。