NMP促进N-肉桂酰胺的合成研究

Study on NMP promoting synthesis of N-cinnamamide derivatives

在N-甲基吡咯烷酮的促进下,肉桂酸与草酰氯在10℃酰氯化反应1 h后,再与加入的胺在35℃酰胺化反应4 h得到目标化合物N-肉桂酰胺;目标化合物结构经(1)^H NMR、(13)^C NMR,IR和EI-MS等表征;同时提出了NMP促进反应的可能机理。该方法具有反应条件温和、操作简便和反应时间短等优点。

Compounds N-cinnamamide were synthesized through the reaction of cinnamic acid with oxalyl chloride at 10℃for 1 h using N-methyl pyrrolidone as the reactive promotor,followed by amidation with amine at 35℃for 4 h.The title compounds were characterized by(1)^H NMR,(13)^C NMR,IR and EI-MS.A mechanism for the NMP promoting reaction of cinnamic acid with amine was put forward.The main advantages of the developed methodology were under mild reaction conditions,simple work-up procedure and short reaction time.