社区高龄老人睡眠障碍流行情况的Meta分析

Prevalence of sleep disorder in community dwelling elderly people over 80 years:A Meta-analysis

背景目前高龄老人(≥80岁)睡眠障碍受到关注广泛,但既往研究一定程度上受到样本量大小、经费及研究地区差异等因素的限制,高龄老人睡眠障碍流行特征尚无系统的研究和分析。目的采用Meta分析的方法估算高龄老人睡眠障碍率。方法系统检索中英文数据库(Pubmed、知网等)和各国政府公共卫生相关部分网站在2000年1月1日-2022年5月31日发表的高龄老人睡眠障碍流行情况的相关文献,根据异质性选择随机效应拟合计算合并值。结果共纳入25篇文献(中文7篇,英文18篇)符合标准进行Meta分析,包括52617名高龄老人。Meta分析显示,高龄老人睡眠障碍率为28.8%(95%CI:23.4%~34.9%)。亚组分析显示女性睡眠障碍患病率高于男性[32.2%(26.6%~38.5%)vs 29.8%(23.3%~37.3%)];国内研究报告的睡眠障碍率高于国外[33.5%(25.9%~41.6%)vs 22.8%(17.0%~29.9%)]。结论高龄老人中睡眠障碍流行,应进一步关注和探索高龄老人乃至百岁老人睡眠障碍流行分布特征及其与长寿及健康结局的关联。

Background Previous studies on sleep disorders in the elderly(≥80 years old)have received extensive attention,however,there is no systematic study and analysis on the prevalence of sleep disorders in the elderly due to the limitation of sample size,funding and regional differences.Objective To estimate the sleep disorder prevalence of the elderly(≥80 years old)by meta-analysis.Methods The Chinese and English databases(Pubmed,Wiley,EMBase,Cochrane Library,CNKI,Wanfang,VIP,websites of ministries of health/ministries of public health/Centers for Disease Control and Prevention of various governments,and websites of the National Health Commission of China)were systematically retrieved.The relevant literatures on the prevalence of sleep disorders in the elderly were searched from January 1,2000 to May 31,2022.The combined values were calculated by random effect fitting according to heterogeneity.Results A total of 25 articles(7 Chinese articles and 18 English articles)were included in the meta-analysis,including 52617 elderly people over 80 years.Meta analysis showed that the sleep disorder prevalence rate of the elderly was 28.8%(95%CI:23.4%-34.9%).Subgroup analysis showed the female had higher sleep disorder prevalence rate than the male(32.2%[95%CI:26.6%-38.5%]vs 29.8%[95%CI:23.3%-37.3%]),and the domestic studies had higher prevalence rate compared to the foreign studies(33.5%[95%CI:25.9%-41.6%]vs 22.8%[95%CI:17.0%-29.9%]).Conclusion The prevalence of sleep disorders among the elderly should be further concerned and explored in the prevalence and distribution of sleep disorders among the elderly and even the centenarians,as well as their association with longevity and health outcomes.