穿心莲内酯衍生物的合成及活性研究进展

Research progress on synthesis and activity of andrographolide derivatives

穿心莲内酯为我国传统中药穿心莲的主要活性成分之一。近年来,许多研究小组以穿心莲内酯为先导化合物,在抗肿瘤、抗炎、抗菌和抗病毒药物的开发方面进行了大量的实验研究。本文对近年来穿心莲内酯衍生物的合成及活性研究进展进行了系统的总结,并揭示其构效关系,以期为进一步基于穿心莲内酯开发新药提供一定的指导。

In recent years,many research groups have carried out a large number of experimental studies based on andrographolide as a lead compound in the development of antitumor,anti-inflammatory,antibacterial and antiviral drugs.In order to provide some guidance for the further research and development of new drugs based on andrographolide,this paper systematically summarizes the research progress in the synthesis and activity of andrographolide derivatives in recent years and reveals their structure-activity relationship.