加味黄连温胆汤治疗有口苦症状胆汁反流性胃炎的临床观察

Clinical Observation of Jiawei Huanglian Wendan Decoction in Treating Bile Reflux Gastritis with Bitter Mouth Symptoms

目的通过观察加味黄连温胆汤对有口苦症状胆汁反流性胃炎的治疗效果,为临床应用提供参考。方法根据症状、胃镜检查及中医证素诊断,使用随机数字表法将符合纳入标准的60例患者分为观察组和对照组各30例,其中观察组使用加味黄连温胆汤治疗,对照组使用铝碳酸镁片治疗,疗程均为4周。治疗前后2组单项症状积分、中医证候积分、胃镜积分及胆汁反流程度作为疗效评定和临床观察的指标。结果2组患者口苦以及相关症状、内镜下表现、胆汁反流程度均较治疗前明显好转,在口苦症状的改善、降低中医证候积分和胃镜积分方面,观察组优于对照组(P<0.05),观察组临床总有效率90.00%,对照组临床总有效率70.00%,2组比较差异有统计学意义(P<0.05)。结论在证素辨证的基础上,应用加味黄连温胆汤治疗有口苦症状的胆汁反流性胃炎,可明显缓解口苦症状及胆汁反流程度,降低中医证候积分和胃镜积分,临床疗效显著。

Objective By observing the therapeutic effect of Jiawei Huanglian Wendan Decoction on bile reflux gastritis with symptoms of bitterness in the mouth,it can provide reference for clinical application.Methods According to symptoms,gastroscopy and TCM syndrome diagnosis,60 patients who met the inclusion criteria were divided into the observation group and the control group with 30 cases in each group by random number table method.The observation group was treated with Jiawei Huanglian Wendan Decoction,while the control group was treated with Hydrotalcite treatment,the course of treatment for 4 weeks.Before and after treatment,the individual symptom scores,TCM syndrome scores,gastroscopy scores and the degree of bile reflux in the two groups were used as indexes for efficacy evaluation and clinical observation.Results Bitter mouth and related symptoms,endoscopic manifestations,and bile reflux degree of patients in both groups were significantly improved compared with those before treatment,and the observation group was better than the control group in terms of improvement of symptoms of mouth pain and reduction of TCM syndrome scores and gastroscopic scores(P<0.05),the total clinical effective rate of the observation group was 90.00%,and the total clinical effective rate of the control group was 70.00%,and the difference between the two groups was statistically significant(P<0.05).Conclusion On the basis of syndrome differentiation,the application of Jiawei Huanglian Wendan Decoction in the treatment of bile reflux gastritis with symptoms of bitterness in the mouth can significantly relieve the symptoms of bitterness in the mouth and the degree of bile reflux,reduce the TCM syndrome score and gastroscope score,and has a significant clinical effect.