Spondin2与肿瘤的研究进展

Research progress of Spondin2 in tumor

脊椎蛋白2(Spondin2)又称Mindin,是一种高度保守的细胞外基质蛋白,属于Mindin/F-spondin家族成员。Spondin2的F底板反应蛋白(F-spondin,FS)结构域介导整合素的结合,并代表了一种新的整合素配体。Spondin2通过与细胞表面整合素受体相互作用,激活下游信号通路,参与肿瘤细胞骨架重塑,进而改变肿瘤细胞的生命活动。既往研究表明,Spondin2在各种实体肿瘤中存在显著差异表达,是一种潜在肿瘤标志物,本文就Spondin2作为诊断预测分子及其在不同的肿瘤微环境中产生的不同作用进行综述。

Spondin2,also known as Mindin,is a highly conserved extracellular matrix protein and a member of the Mindin/F-spondin family. The F-spondin(FS)domain of Spondin2 mediates integrin binding and represents a novel integrin ligand. Spondin2 interacts with cell surface integrin receptors to activate downstream signaling pathways and participate in the remodeling of tumor cytoskeleton,thereby altering the life activities of tumor cells. Previous studies have shown that Spondin2 is a potential tumor marker with significant differential expression in a variety of solid tumors. This paper reviews Spondin2 as a diagnostic predictive molecule and its different roles in different tumor microenvironments.